Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL036003-12
Application #
2217986
Study Section
Pathology A Study Section (PTHA)
Project Start
1991-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Pathology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
D'Alessio, Alessio; Esposito, Bianca; Giampietri, Claudia et al. (2012) Plasma membrane microdomains regulate TACE-dependent TNFR1 shedding in human endothelial cells. J Cell Mol Med 16:627-36
Pober, Jordan S; Tellides, George (2012) Participation of blood vessel cells in human adaptive immune responses. Trends Immunol 33:49-57
Al-Lamki, R S; Brookes, A P; Wang, J et al. (2009) TNF receptors differentially signal and are differentially expressed and regulated in the human heart. Am J Transplant 9:2679-96
Li, Jie H; D'Alessio, Alessio; Pober, Jordan S (2009) Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells. Am J Pathol 175:1124-35
Ding, Bo; Kirkiles-Smith, Nancy C; Pober, Jordan S (2009) FOXO3a regulates oxygen-responsive expression of tumor necrosis factor receptor 2 in human dermal microvascular endothelial cells. J Biol Chem 284:19331-9
Clark, Paul R; Pober, Jordan S; Kluger, Martin S (2008) Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect. Nucleic Acids Res 36:1081-97
Enis, David R; Dunmore, Benjamin; Johnson, Nicola et al. (2008) Antiapoptotic activities of bcl-2 correlate with vascular maturation and transcriptional modulation of human endothelial cells. Endothelium 15:59-71
Zhang, Haifeng; Zhang, Rong; Zhang, Haifeng et al. (2007) RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation. J Biol Chem 282:14788-96
Enis, David R; Shepherd, Benjamin R; Wang, Yinong et al. (2005) Induction, differentiation, and remodeling of blood vessels after transplantation of Bcl-2-transduced endothelial cells. Proc Natl Acad Sci U S A 102:425-30
D'Alessio, Alessio; Al-Lamki, Rafia S; Bradley, John R et al. (2005) Caveolae participate in tumor necrosis factor receptor 1 signaling and internalization in a human endothelial cell line. Am J Pathol 166:1273-82

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