This application addresses broad Challenge Area (03): Biomarker Discovery and Validation and specific Challenge Topic, 03-ES-101: Validation of New Exposure Assessment Methodologies. Despite evidence of widespread dietary exposure among children and adults, little is currently known about dietary exposure of infants to pesticides. This project will address the current gap in knowledge by validating methods for measuring current use pesticides in breast milk and infant formula. Although the breast milk method will be pilot tested on samples collected from a birth cohort in Thailand, it will have broad applications for the U.S. population. Because these pesticides are widely distributed in the food supply, all U.S. infants are potentially exposed. A valid method for measuring these compounds in breast milk and formula would have a major impact on our ability to evaluate pesticide exposures in early life, contributing to an improved understanding of their longer-term health effects.

Public Health Relevance

Little is known about the dietary exposures of infants to pesticides, despite their vulnerability to chemical insults and despite evidence of widespread dietary exposure among older children and adults. This project will address the current gap in knowledge by validating methods for measuring pesticides in breast milk and infant formula. Such methods would have a major impact on our ability to evaluate pesticide exposures in early life, contributing to an improved understanding of their longer-term health effects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
NIH Challenge Grants and Partnerships Program (RC1)
Project #
5RC1ES018299-02
Application #
7936936
Study Section
Special Emphasis Panel (ZRG1-BBBP-J (58))
Program Officer
Shaughnessy, Daniel
Project Start
2009-09-21
Project End
2012-06-30
Budget Start
2010-07-01
Budget End
2012-06-30
Support Year
2
Fiscal Year
2010
Total Cost
$238,013
Indirect Cost
Name
Emory University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Naksen, Warangkana; Prapamontol, Tippawan; Mangklabruks, Ampica et al. (2016) A single method for detecting 11 organophosphate pesticides in human plasma and breastmilk using GC-FPD. J Chromatogr B Analyt Technol Biomed Life Sci 1025:92-104
Panuwet, Parinya; Siriwong, Wattasit; Prapamontol, Tippawan et al. (2012) Agricultural Pesticide Management in Thailand: Situation and Population Health Risk. Environ Sci Policy 17:72-81