Tennessee State University is a historically Black university with a high minority enrollment, better than 80% minority undergraduate students and 57% minority graduate students. As a result, the University has a goal/ responsibility to address underrepresentation of these students in all academic career areas. The overall goal of the TSU SCORE program is to assist the University in addressing underrepresentation of minority students in biomedical research through support of ongoing research by faculty in the Departments of Biology and Chemistry.
The specific aims of the proposed continuing TSU SCORE program are to: (1) increase the number of funded faculty biomedical research projects via the SCORE program from the current 2 to 8 faculty;(2) increase the research competitiveness of 8 faculty members such that within an 8-year period, they will be able to gain competitive extramural support of their ongoing research programs;and (3) increase the average annual number of peer-reviewed publications per investigator. Two research subprojects in this application represent the Departments of Biological Sciences and Chemistry, which are housed in the College of Arts and Sciences of the University. Research topics include retinoic acid receptors in neurogenesis in the post-natal olfactory epithelium and inhibition of human natural killer cells by butyltins.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM008092-35
Application #
7826943
Study Section
Minority Programs Review Committee (MPRC)
Program Officer
Zlotnik, Hinda
Project Start
1997-04-01
Project End
2012-04-30
Budget Start
2010-05-01
Budget End
2012-04-30
Support Year
35
Fiscal Year
2010
Total Cost
$253,929
Indirect Cost
Name
Tennessee State University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
108814179
City
Nashville
State
TN
Country
United States
Zip Code
37209
Rana, Krupa; Whalen, Margaret (2015) Activation of protein kinase C and protein kinase D in human natural killer cells: effects of tributyltin, dibutyltin, and tetrabromobisphenol A. Toxicol Mech Methods 25:680-8
Hurd-Brown, Tasia; Udoji, Felicia; Martin, Tamara et al. (2013) Effects of DDT and triclosan on tumor-cell binding capacity and cell-surface protein expression of human natural killer cells. J Appl Toxicol 33:495-502
Sharow, Kyle A; Temkin, Boris; Asson-Batres, Mary Ann (2012) Retinoic acid stability in stem cell cultures. Int J Dev Biol 56:273-8
Hurd, Tasia; Walker, Jasmine; Whalen, Margaret M (2012) Pentachlorophenol decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells. J Appl Toxicol 32:627-34
Taylor, Thyneice R; Whalen, Margaret M (2011) Ziram activates mitogen-activated protein kinases and decreases cytolytic protein levels in human natural killer cells. Toxicol Mech Methods 21:577-84
Buchanan, FaMitah Q; Rochette-Egly, Cecile; Asson-Batres, Mary Ann (2011) Detection of variable levels of RAR? and RAR? proteins in pluripotent and differentiating mouse embryonal carcinoma and mouse embryonic stem cells. Cell Tissue Res 346:43-51
Hurd, Tasia; Whalen, Margaret M (2011) Tetrabromobisphenol A decreases cell-surface proteins involved in human natural killer (NK) cell-dependent target cell lysis. J Immunotoxicol 8:219-27
Person, Rachel J; Whalen, Margaret M (2010) Effects of butyltin exposures on MAP kinase-dependent transcription regulators in human natural killer cells. Toxicol Mech Methods 20:227-33
Udoji, Felicia; Martin, Tamara; Etherton, Rachel et al. (2010) Immunosuppressive effects of triclosan, nonylphenol, and DDT on human natural killer cells in vitro. J Immunotoxicol 7:205-12
Abraha, Abraham B; Rana, Krupa; Whalen, Margaret M (2010) Role of protein kinase C in TBT-induced inhibition of lytic function and MAPK activation in human natural killer cells. Arch Environ Contam Toxicol 59:661-9

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