This proposal consists of an enrichment component and three scientific subprojects. The enrichment component entails seminars and workshops by visiting scientists at ASU campus, faculty participation in short laboratory-oriented courses and """"""""retooling"""""""" experiences at off-campus research institutions, and student participation in extramural research during the summer at major universities in the United States. The students (and faculty) will also attend national scientific meetings and participate in the institution's Biomedical Science Club. In the scientific subproject #1, trace and major element concentrations in blood and other tissues and body fluids in healthy pregnant and nonpregnant rats will be measured by the Proton Induced X-ray Emission Technique in order to determine the elemental imbalances, and the role and interrelations of trace and major elements during pregnancy. The major goal of the second subproject is to elucidate the biochemical mechanisms by which biotin mediates mitogenesis in Rous sarcoma virus- transformed hamster cells. The third subproject deals with the use of monoclonal antibodies, raised against the surface and buried epitopes of OmpD and OmpC porins, to elucidate the role of major outer membrane proteins in immune response to infection by Salmonella. The objectives of the overall proposal are: 1. To increase and strengthen the biomedical research capabilities of the institution. 2. To provide support for the faculty to conduct biomedical research and train students on campus. 3. To provide opportunities for minority students to participate in biomedical research. 4. To better prepare minority students for graduate studies in biomedical sciences. 5. To improve the intellectual and scientific environment in the areas of natural sciences at Alabama State University.
|Wu, Hongzhuan; Dennis, Vida A; Pillai, Shreekumar R et al. (2009) RSV fusion (F) protein DNA vaccine provides partial protection against viral infection. Virus Res 145:39-47|
|Taha, Murtada; McMillon, Ronald; Napier, Audrey et al. (2009) Extracts from salivary glands stimulate aggression and inositol-1, 4, 5-triphosphate (IP3) production in the vomeronasal organ of mice. Physiol Behav 98:147-55|
|Lee, Kyoung G; Pillai, Shreekumar R; Singh, Shree R et al. (2008) The investigation of Protein A and Salmonella antibody adsorption onto biosensor surfaces by atomic force microscopy. Biotechnol Bioeng 99:949-59|
|Singh, Shree R; Dennis, Vida A; Carter, Christina L et al. (2007) Immunogenicity and efficacy of recombinant RSV-F vaccine in a mouse model. Vaccine 25:6211-23|
|Singh, Shree R; Dennis, Vida A; Carter, Christina L et al. (2007) Respiratory syncytial virus recombinant F protein (residues 255-278) induces a helper T cell type 1 immune response in mice. Viral Immunol 20:261-75|
|Thompson, Roger N; Napier, Audrey; Wekesa, Kennedy S (2007) Chemosensory cues from the lacrimal and preputial glands stimulate production of IP3 in the vomeronasal organ and aggression in male mice. Physiol Behav 90:797-802|