For many years our laboratory has investigated the chemistry of certain natural products from plants and microorganisms. The rationale for these investigations is that the natural products possess unique biological properties. We will continue our investigations of steroidal plant-growth hormones (brassinosteroids). Several of these steroids have been synthesized in our laboratory. We hope to synthesize tritiated brassinolide and to use this compound to search for the receptor of the hormone in plant cells. Investigation of new anticancer agents derived from the fungal sesquiterpene illudin S will continue. We have identified two derivatives which show great promise in treatment of solid tumors. We plan to prepare more derivatives and to study the mechanism of their anticancer action.

Project Start
1998-02-01
Project End
1999-01-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
7
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Mathieu-Costello, O; Morales, S; Savolainen, J et al. (2002) Fiber capillarization relative to mitochondrial volume in diaphragm of shrew. J Appl Physiol 93:346-53
Chang, N; Uribe, J M; Keely, S J et al. (2001) Insulin and IGF-I inhibit calcium-dependent chloride secretion by T84 human colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol 281:G129-37
McMorris, T C; Lira, R; Gantzel, P K et al. (2000) Sesquiterpenes from the basidiomycete Omphalotus illudens. J Nat Prod 63:1557-9
Buck, M; Kim, D J; Houglum, K et al. (2000) c-Myb modulates transcription of the alpha-smooth muscle actin gene in activated hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 278:G321-8
Houglum, K; Buck, M; Kim, D J et al. (1998) TNF-alpha inhibits liver collagen-alpha 1(I) gene expression through a tissue-specific regulatory region. Am J Physiol 274:G840-7
Chojkier, M; Houglum, K; Lee, K S et al. (1998) Long- and short-term D-alpha-tocopherol supplementation inhibits liver collagen alpha1(I) gene expression. Am J Physiol 275:G1480-5
Houglum, K; Lee, K S; Chojkier, M (1997) Proliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on serine 133. J Clin Invest 99:1322-8
Lin, V S; Motesharei, K; Dancil, K P et al. (1997) A porous silicon-based optical interferometric biosensor. Science 278:840-3
Otonkoski, T; Cirulli, V; Beattie, M et al. (1996) A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth. Endocrinology 137:3131-9
Lee, K S; Buck, M; Houglum, K et al. (1995) Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 96:2461-8

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