The broad long term objective of this research is to characterize the effects of aging on renal drug excretion. Although it is well established that becoming older is accompanied by anatomic and physiologic changes in renal function, there is a paucity of data regarding the differential effects of aging on the individual mechanisms of renal excretion of medications: filtration, secretion and reabsorption. The first specific aim of the research is to establish the isolated perfiised rat kidney (IPK) model as a useful tool for studying the effects of aging on physiologic renal function and renal clearance. Establishing the IPK as a model of renal drug disposition in geriatric subjects would allow correlation between aging and the numerous factors which affect renal drug excretion.
A second aim of the research is to test the validity of the """"""""Whole Nephron Hypothesis"""""""" which assumes that reductions in glomerular filtration secondary to aging or disease are accompanied by parallel reductions in secretion and reabsorption. Whereas this hypothesis is the basis for making dosage adjustments based on glomerular filtration rate (GFR), reports in the literature suggest that tubular secretion of certain medications can be maintained in the presence of decreased OFR. Studying the effects of aging on the renal excretion para-aminohippurate and acetazolamide, compounds of contrasting degrees of renal extraction, will permit assessment of the linearity between filtration and secretory mechanisms of the kidney. These findings could challenge present guidelines for GFR-based dosing of medications in geriatric patients and possibly reduce the incidence of drug-related morbidity in this patient population.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Minority Biomedical Research Support - MBRS (S06)
Project #
5S06GM054650-05
Application #
6356553
Study Section
Minority Programs Review Committee (MPRC)
Project Start
2000-09-30
Project End
2001-09-29
Budget Start
Budget End
Support Year
5
Fiscal Year
2000
Total Cost
$101,626
Indirect Cost
Name
Long Island University Brooklyn Campus
Department
Type
DUNS #
City
Brooklyn
State
NY
Country
United States
Zip Code
11548
Ratna, Warren N; Bhatt, Vrushank D; Chaudhary, Kawshik et al. (2016) Estrogen-responsive genes encoding egg yolk proteins vitellogenin and apolipoprotein II in chicken are differentially regulated by selective estrogen receptor modulators. Theriogenology 85:376-83
Cohen, Carl I; Ryu, Helen H (2015) A Longitudinal Study of the Outcome and Associated Factors of Subsyndromal and Syndromal Depression in Community-Dwelling Older Adults with Schizophrenia Spectrum Disorder. Am J Geriatr Psychiatry 23:925-33
Tuck, Natalie L; Consedine, Nathan S (2015) Breast cancer screening: the role of attachment. Psychol Health Med 20:400-9
Cohen, Carl I; Iqbal, Mudassar (2014) Longitudinal study of remission among older adults with schizophrenia spectrum disorder. Am J Geriatr Psychiatry 22:450-8
Cohen, Carl I; Natarajan, Navin; Araujo, Marie et al. (2013) Prevalence of negative symptoms and associated factors in older adults with schizophrenia spectrum disorder. Am J Geriatr Psychiatry 21:100-7
Cohen, Carl I; Solanki, Dishal; Sodhi, Dimple (2013) Interpersonal conflict strategies and their impact on positive symptom remission in persons aged 55 and older with schizophrenia spectrum disorders. Int Psychogeriatr 25:47-53
Consedine, Nathan S; Fiori, Katherine L; Tuck, Natalie L et al. (2013) Attachment, activity limitation, and health symptoms in later life: the mediating roles of negative (and positive) affect. J Aging Health 25:56-79
Merz, Eva-Maria; Consedine, Nathan S (2012) Ethnic group moderates the association between attachment and well-being in later life. Cultur Divers Ethnic Minor Psychol 18:404-15
Consedine, Nathan S (2012) The demographic, system, and psychosocial origins of mammographic screening disparities: prediction of initiation versus maintenance screening among immigrant and non-immigrant women. J Immigr Minor Health 14:570-82
Consedine, Nathan S; Fiori, Katherine L; Magai, Carol (2012) Regulating emotion expression and regulating emotion experience: divergent associations with dimensions of attachment among older women. Attach Hum Dev 14:477-500

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