Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR011248-01
Application #
2286832
Study Section
Special Emphasis Panel (ZRG7-SSS-7 (32))
Project Start
1996-09-30
Project End
1997-09-29
Budget Start
1996-09-30
Budget End
1997-09-29
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Carnegie-Mellon University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
052184116
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Sahu, Sarata C; Simplaceanu, Virgil; Gong, Qingguo et al. (2006) Orientation of deoxyhemoglobin at high magnetic fields: structural insights from RDCs in solution. J Am Chem Soc 128:6290-1
Lukin, Jonathan A; Ho, Chien (2004) The structure--function relationship of hemoglobin in solution at atomic resolution. Chem Rev 104:1219-30
Barrick, Doug; Lukin, Jonathan A; Simplaceanu, Virgil et al. (2004) Nuclear magnetic resonance spectroscopy in the study of hemoglobin cooperativity. Methods Enzymol 379:28-54
Lukin, Jonathan A; Kontaxis, Georg; Simplaceanu, Virgil et al. (2004) Backbone resonance assignments of human adult hemoglobin in the carbonmonoxy form. J Biomol NMR 28:203-4
Lukin, Jonathan A; Kontaxis, Georg; Simplaceanu, Virgil et al. (2003) Quaternary structure of hemoglobin in solution. Proc Natl Acad Sci U S A 100:517-20
Tsai, Ching-Hsuan; Simplaceanu, Virgil; Ho, Nancy T et al. (2003) Site mutations disrupt inter-helical H-bonds (alpha14W-alpha67T and beta15W-beta72S) involved in kinetic steps in the hemoglobin R-->T transition without altering the free energies of oxygenation. Biophys Chem 100:131-42
Yuan, Yue; Simplaceanu, Virgil; Lukin, Jonathan A et al. (2002) NMR investigation of the dynamics of tryptophan side-chains in hemoglobins. J Mol Biol 321:863-78
Chang, Chung-ke; Simplaceanu, Virgil; Ho, Chien (2002) Effects of amino acid substitutions at beta 131 on the structure and properties of hemoglobin: evidence for communication between alpha 1 beta 1- and alpha 1 beta 2-subunit interfaces. Biochemistry 41:5644-55
Tang, Pei; Mandal, Pravat K; Xu, Yan (2002) NMR structures of the second transmembrane domain of the human glycine receptor alpha(1) subunit: model of pore architecture and channel gating. Biophys J 83:252-62
Hitchens, T K; Mannervik, B; Rule, G S (2001) Disorder-to-order transition of the active site of human class Pi glutathione transferase, GST P1-1. Biochemistry 40:11660-9

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