This proposal requests support for continuation of a training program which is currently in its fifth year and focuses on the biology of aging and/or age related diseases. Although the faculty trainers involved are from disparate academic homes within our University, each is recognized for excellence in research, and each is committed to examining questions related to biogerontology. The initial proposal funded four post-doctoral slots and the addition of three pre-doctoral slots. The rationale for this is based on the expanded growth of the biogerontology discipline on this campus. One of the four pre-doctoral slots will be dedicated to the MD/Ph.D. student, and the other three will be interdisciplinary programs relevant to gerontology (e.g., Cell and Molecular Biology, Nutritional Sciences.) Each trainee will be required to complete a minor in gerontology. The strengths of this training grant include the infrastructure provided by the UW Institute on Aging, an energetic and collegial faculty, and outstanding students. We have also developed a strategy to recruit minority students and post-doctoral fellows and a rigorous approach to exposure and discussion of issues in bioethics. Furthermore, the support of an MD/Ph.D. student may prove to be an excellent mechanism to recruit the brightest of our medical students into biogerontology or geriatric medicine.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Institutional National Research Service Award (T32)
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Study Section
Biological and Clinical Aging Review Committee (BCA)
Program Officer
Sierra, Felipe
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University of Wisconsin Madison
Other Health Professions
Schools of Medicine
United States
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Kosoff, David; Lang, Joshua M (2018) Development and translation of novel therapeutics targeting tumor-associated macrophages. Urol Oncol :
Peng, Yajing; Shapiro, Samantha L; Banduseela, Varuna C et al. (2018) Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype. Aging Cell 17:e12820
Rhoads, Timothy W; Burhans, Maggie S; Chen, Vincent B et al. (2018) Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys. Cell Metab 27:677-688.e5
Martin, Stephen A; Souder, Dylan C; Miller, Karl N et al. (2018) GSK3? Regulates Brain Energy Metabolism. Cell Rep 23:1922-1931.e4
Farrugia, Mark A; Puglielli, Luigi (2018) N?-lysine acetylation in the endoplasmic reticulum - a novel cellular mechanism that regulates proteostasis and autophagy. J Cell Sci 131:
Kosoff, David; Yu, Jiaquan; Suresh, Vikram et al. (2018) Surface topography and hydrophilicity regulate macrophage phenotype in milled microfluidic systems. Lab Chip 18:3011-3017
Yu, Deyang; Yang, Shany E; Miller, Blake R et al. (2018) Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms. FASEB J 32:3471-3482
Cummings, Nicole E; Williams, Elizabeth M; Kasza, Ildiko et al. (2018) Restoration of metabolic health by decreased consumption of branched-chain amino acids. J Physiol 596:623-645
Loewen, Carin A; Ganetzky, Barry (2018) Mito-Nuclear Interactions Affecting Lifespan and Neurodegeneration in a Drosophila Model of Leigh Syndrome. Genetics 208:1535-1552
Neuman, Joshua C; Schaid, Michael D; Brill, Allison L et al. (2017) Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E2 Signaling and Enhances Diabetic ?-Cell Function. Diabetes 66:1572-1585

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