The proposed research training program will provide post-doctoral training in clinical research regarding the neurobehavior, neuroendocrinology, and neurogenetics of Alzheimer's Disease (AD) and related dementias. In particular, the program will focus on training clinical researchers capable of translating critical findings from basic science into hypotheses regarding the etiology, pathophysiology, and treatment of AD. Furthermore, clinical researchers will receive specialized training in two areas of study, neuroendocrinology and neurogenetics, that hold promise for increasing our understanding of the pathogenesis of AD and for developing new therapeutic approaches. Recent advances have underscored the importance of genetic factors such as amyloid precursor protein and presenilin mutations, and apolipoprotein epsilon genotype. Neuroendocrine factors such as estrogenic, glucoregulatory, and glucocorticoid status may also play an important pathogenetic role in modulating AD susceptibility genes, and thereby affect the neuropsychologic expression of AD. Clinical investigators capable of bridging the fields of neurogenetics, neuropsychology, and neuroendocrinology will be needed to disentangle and define these potentially critical interactions. The program will take place in the rich and interactive research environment of the University of Washington and the Veterans Affairs Puget Sound Health Care System, where a critical mass of faculty conduct both basic science and clinical research in the neuroendocrinology and neurogenetics of AD. The Alzheimer's Disease Research Center at the University of Washington will also serve as a resource for faculty and trainees. Given the interdisciplinary focus of the program, both Ph.D. and M.D. fellows will be included. As a new program, the number of slots has been restricted to two M.D. fellows and three Ph.D. post-doctoral fellows. M.D. fellowship candidates will have completed residency training in psychiatry or neurology, whereas Ph.D. fellowship candidates will have completed residency training in psychiatry or neurology, whereas Ph.D. fellowship candidates will have completed doctoral training in neuropsychology, geropsychology, cognitive aging, neuroendocrinology, or human genetics. All fellows will be required to completed a minimum of two years of fellowship, and additional years will be strongly encouraged. Although there is a long-standing commitment to aging training at our institution, our program is unique in its interdisciplinary nature and focus on clinical translational research in AD and related conditions. As such, it will provide a much-needed approach to the training of clinical research scientists whose work will address these complex disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AG000258-04
Application #
6509333
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Miller, Marilyn
Project Start
1999-06-15
Project End
2004-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
4
Fiscal Year
2002
Total Cost
$250,373
Indirect Cost
Name
University of Washington
Department
Psychiatry
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Boord, Peter; Madhyastha, Tara M; Askren, Mary K et al. (2017) Executive attention networks show altered relationship with default mode network in PD. Neuroimage Clin 13:1-8
Latimer, Caitlin S; Flanagan, Margaret E; Cimino, Patrick J et al. (2017) Neuropathological Comparison of Adult Onset and Juvenile Huntington's Disease with Cerebellar Atrophy: A Report of a Father and Son. J Huntingtons Dis 6:337-348
Huber, B R; Meabon, J S; Hoffer, Z S et al. (2016) Blast exposure causes dynamic microglial/macrophage responses and microdomains of brain microvessel dysfunction. Neuroscience 319:206-20
Meabon, James S; de Laat, Rian; Ieguchi, Katsuaki et al. (2016) Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling. Mol Cell Neurosci 70:1-10
Melief, E J; Gibbs, J T; Li, X et al. (2016) Characterization of cognitive impairments and neurotransmitter changes in a novel transgenic mouse lacking Slc10a4. Neuroscience 324:399-406
Hanson, Angela J; Banks, William A; Hernandez Saucedo, Hector et al. (2016) Apolipoprotein E Genotype and Sex Influence Glucose Tolerance in Older Adults: A Cross-Sectional Study. Dement Geriatr Cogn Dis Extra 6:78-89
Meabon, James S; Huber, Bertrand R; Cross, Donna J et al. (2016) Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction. Sci Transl Med 8:321ra6
Melief, Erica J; Cudaback, Eiron; Jorstad, Nikolas L et al. (2015) Partial depletion of striatal dopamine enhances penetrance of cognitive deficits in a transgenic mouse model of Alzheimer's disease. J Neurosci Res 93:1413-22
Gross, Alden L; Benitez, Andreana; Shih, Regina et al. (2015) Predictors of Retest Effects in a Longitudinal Study of Cognitive Aging in a Diverse Community-Based Sample. J Int Neuropsychol Soc 21:506-18
Salameh, Therese S; Bullock, Kristin M; Hujoel, Isabel A et al. (2015) Central Nervous System Delivery of Intranasal Insulin: Mechanisms of Uptake and Effects on Cognition. J Alzheimers Dis 47:715-28

Showing the most recent 10 out of 69 publications