The proposed program represents a 5-year continuation of an institutional training grant in the biology of aging, which was consolidated in 2003 from two departmental training grants. We request funds to support 10 predoctoral and 6 postdoctoral trainees. The impending avalanche of elderly in the US combined with major recent advances in understanding fundamental mechanisms of aging has created a substantial demand for researchers trained to investigate means of delaying and relieving the ailments of an aging population. The University of Texas Health Science Center at San Antonio is a premier research institution in the biology of aging, currently receiving more research funding from the Biology of Aging Program of the National Institute on Aging (NIA)than any other stand-alone medical institution. The primary goal of the proposed Training Program is to intellectually prepare both graduate students and postdoctoral fellows for careers as leaders in basic biological research in aging. The Training Program involves 25 faculty members (14 men, 11 women) and takes advantage of the synergies created by intensely collaborative personnel, the unique resources available from our Nathan Shock Center of Excellence in the Biology of Aging and the institutional commitment to, and expanding resources of, the Barshop Institute itself. Trainees will be chosen competitively based on academic excellence, their interest in aging research, and motivation for careers in research. The main activity of each trainee is the development of their faculty-supervised research project, which because of the extent of collaboration among our faculty tends to result surprisingly often in team mentorships. Another key component is to require broad knowledge in the biology of aging acquired in our two biology of aging courses such that trainees'can place their research in an appropriate scientific context. In addition to this formal didactic training, we require trainees to attend the weekly Aging Research Journal Club and the Barshop Institute seminar series. Our program also emphasizes training in scientific communication with multiple venues for trainees to hone skills in both written and oral presentation. The timing of the proposed Training Program is propitious in that it will span the transition of our graduate student program from its current status as a Special Biology of Aging Track within the Department of Cellular &Structural Biology to its future status as an independent graduate program - the nation's first Ph.D.program in the Biology of Aging. That transition process has already been initiated and will be completed during the proposed funding period.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AG021890-10
Application #
8248749
Study Section
Special Emphasis Panel (ZAG1-ZIJ-9 (J1))
Program Officer
Velazquez, Jose M
Project Start
2003-05-01
Project End
2013-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
10
Fiscal Year
2012
Total Cost
$237,776
Indirect Cost
$49,124
Name
University of Texas Health Science Center San Antonio
Department
Biology
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Lewis, Kaitlyn N; Rubinstein, Nimrod D; Buffenstein, Rochelle (2018) A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence. Geroscience 40:105-121
Garbarino, Valentina R; Gilman, T Lee; Daws, Lynette C et al. (2018) Extreme enhancement or depletion of serotonin transporter function and serotonin availability in autism spectrum disorder. Pharmacol Res :
Jahrling, Jordan B; Lin, Ai-Ling; DeRosa, Nicholas et al. (2018) mTOR drives cerebral blood flow and memory deficits in LDLR-/- mice modeling atherosclerosis and vascular cognitive impairment. J Cereb Blood Flow Metab 38:58-74
Van Skike, Candice E; Jahrling, Jordan B; Olson, Angela B et al. (2018) Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol 314:H693-H703
Zhang, Shen-Ying; Clark, Nathaniel E; Freije, Catherine A et al. (2018) Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection. Cell 172:952-965.e18
Van Skike, Candice E; Galvan, Veronica (2018) A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review. Gerontology 64:205-211
Deng, Yilun; Qin, Yuejuan; Srikantan, Subramanya et al. (2018) The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex. Hum Mol Genet 27:1794-1808
Kraig, Ellen; Linehan, Leslie A; Liang, Hanyu et al. (2018) A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects. Exp Gerontol 105:53-69
Deepa, Sathyaseelan S; Pharaoh, Gavin; Kinter, Michael et al. (2018) Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice. Aging Cell :e12769
Lin, Ai-Ling; Jahrling, Jordan B; Zhang, Wei et al. (2017) Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease. J Cereb Blood Flow Metab 37:217-226

Showing the most recent 10 out of 124 publications