This renewal application seeks continued support for years 36-40 of the Washington University Training Program in Immunology and Immunogenetics. Washington University has made a strong and lasting commitment to Immunology research and training through the development of an Immunology Graduate Program, responsible for directing graduate education in Immunology and coordinating the Immunology-related activities of the 50 faculty, 135 postdoctoral fellows and 71 graduate students that constitute our Immunology community. The Immunology community at Washington University has achieved a world-recognized status. It is characterized by a collaborative atmosphere that has helped establish an excellent environment for training young Immunologists. This grant and the Washington University Immunology Community have formed a symbiotic relationship where the growth of the community has been catalyzed through the benefits of trainee support afforded by this training grant and the quality of our training program has been enhanced by the growth and interactive nature of the community. This program contains elements that insure the appropriate training of Immunologists at both the predoctoral and postdoctoral levels. Fundamental laboratory research resides at the center of the training experience for both types of candidates. A total of 38 Immunology research faculty are listed on this grant but trainees can work with any of the 50 Immunologists in residence at Washington University. In addition, all trainees participate in University-wide Immunology seminars, journal clubs, work-in-progress meetings and retreats. Predoctoral trainees must complete and show competence in a rigorous curriculum of basic training where they are exposed, through formalized classroom experiences, to historical, modern and emerging concepts of Immunology, related biomedical sciences and research ethics. Postdoctoral trainees are provided with a similar scientific training, but additionally, they are mentored/advised for careers in immunology and a separate ethics course. To insure continuity of the comprehensive Immunology training experience that has been established at this institution, we request renewal of our 10 predoctoral and 6 postdoctoral trainee slots, a number that is unchanged from that of the current funding period. The field of immunology impacts many areas of medical science, including autoimmune diseases, such as diabetes, multiple sclerosis, and rheumatoid arthritis, asthma, allergies, vaccines, and cancer. The training of predoctoral students and postdoctoral fellows is an essential component of this research, and greatly helps today and in the future, the development of treatments and cure for these diseases.
The Training Program in Immunology and Immunogenetics at Washington University in St. Louis seeks continued support to maintain a highly successful mechanism that provides research training to talented students and doctors who wish to pursue careers in immunology research. The program faculty are highly accomplished medical scientists performing state of the art immunology research in a premier world-class medical research institution. The Program over the past 35 years has produced many of today's successful immunology researchers and continued support will insure that this pipeline continues to produce expertly trained scientists who commit themselves to curing major human diseases.
|Wilen, Craig B; Lee, Sanghyun; Hsieh, Leon L et al. (2018) Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science 360:204-208|
|Durai, Vivek; Bagadia, Prachi; Briseño, Carlos G et al. (2018) Altered compensatory cytokine signaling underlies the discrepancy between Flt3-/- and Flt3l-/- mice. J Exp Med 215:1417-1435|
|Huynh, Jeremy P; Lin, Chih-Chung; Kimmey, Jacqueline M et al. (2018) Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection. J Exp Med 215:1823-1838|
|Theisen, Derek J; Davidson 4th, Jesse T; Briseño, Carlos G et al. (2018) WDFY4 is required for cross-presentation in response to viral and tumor antigens. Science 362:694-699|
|Briseño, Carlos G; Satpathy, Ansuman T; Davidson 4th, Jesse T et al. (2018) Notch2-dependent DC2s mediate splenic germinal center responses. Proc Natl Acad Sci U S A 115:10726-10731|
|Fernandez, Estefania; Kose, Nurgun; Edeling, Melissa A et al. (2018) Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus. MBio 9:|
|Yokoyama, Christine C; Baldridge, Megan T; Leung, Daisy W et al. (2018) LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens. J Biol Chem 293:6022-6038|
|Fernandez, Estefania; Diamond, Michael S (2017) Vaccination strategies against Zika virus. Curr Opin Virol 23:59-67|
|Fernandez, Estefania; Dejnirattisai, Wanwisa; Cao, Bin et al. (2017) Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection. Nat Immunol 18:1261-1269|
|Morales, Abigail J; Carrero, Javier A; Hung, Putzer J et al. (2017) A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages. Elife 6:|
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