With this renewal application we request continued support for six pre-doctoral student training slots in support of our Virology Training Program. This renewal will take us into our third decade of continuous support for this training program. Our world-class group of 23 virology mentors provide training opportunities in viral pathogenesis, virus-host interactions, model systems, vaccine development, carcinogenic mechanisms, gene therapy vectors, and rich opportunities for translational research working with a number of important human pathogens. Our goal is to provide laboratory-based training coupled with the development of critical thinking and communication skills to produce outstanding young researchers in virology. Classroom instruction typically consists of three one-semester courses that cover molecular virology, viral pathogenesis, and a special topics course based on student presentations. Students receive additional training in ethics, career development, and the peer review process. A significant fraction of our trainees become proficient in working under BSL3 containment conditions. Our trainees are recruited nationally into an open admissions program where they receive institutional support for the first academic year. Students receive 1-2 years of support from the training grant typically during years 3-5. Trainees meet monthly with the Program Director and Associate Director, and present their research both at national meetings and at our yearly Virology Colloquium. Our trainees are productive, undertake challenging postdoctoral research training, and have gone on to compete for academic faculty position, positions in the pharmaceutical industry and in small biotech companies, and in government. Thus we prepare our students for the entire range of professional opportunities that are available to biomedical scientists.

Public Health Relevance

Viruses represent a major threat to human health. This has been true since the first humans and will continue to be true for the foreseeable future. The threat changes as viruses evolve and human behavior changes to create new transmission routes. Thus there is an ongoing need to train the next generation of scientists to be able to study the viruses that are the cause of morbidity and mortality today, and the new viruses of the future that we can confidently predict will appear.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
4T32AI007419-24
Application #
9067882
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
1993-09-01
Project End
2018-08-31
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
24
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Biochemistry
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Turner, Sarah D; Maurizio, Paul L; Valdar, William et al. (2018) Dissecting the Genetic Architecture of Shoot Growth in Carrot (Daucus carota L.) Using a Diallel Mating Design. G3 (Bethesda) 8:411-426
Maurizio, Paul L; Ferris, Martin T; Keele, Gregory R et al. (2018) Bayesian Diallel Analysis Reveals Mx1-Dependent and Mx1-Independent Effects on Response to Influenza A Virus in Mice. G3 (Bethesda) 8:427-445
Gallichotte, Emily N; Baric, Thomas J; Yount Jr, Boyd L et al. (2018) Human dengue virus serotype 2 neutralizing antibodies target two distinct quaternary epitopes. PLoS Pathog 14:e1006934
Anders, Penny M; Montgomery, Nathan D; Montgomery, Stephanie A et al. (2018) Human herpesvirus-encoded kinase induces B cell lymphomas in vivo. J Clin Invest 128:2519-2534
Arend, Kyle C; Lenarcic, Erik M; Moorman, Nathaniel J (2018) The 5' Untranslated Region of the Major Immediate Early mRNA Is Necessary for Efficient Human Cytomegalovirus Replication. J Virol 92:
Honeycutt, Jenna B; Liao, Baolin; Nixon, Christopher C et al. (2018) T cells establish and maintain CNS viral infection in HIV-infected humanized mice. J Clin Invest 128:2862-2876
Albright, Blake H; Storey, Claire M; Murlidharan, Giridhar et al. (2018) Mapping the Structural Determinants Required for AAVrh.10 Transport across the Blood-Brain Barrier. Mol Ther 26:510-523
Maurizio, Paul L; Ferris, Martin T (2017) The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases. Methods Mol Biol 1488:579-596
Arend, Kyle C; Lenarcic, Erik M; Vincent, Heather A et al. (2017) Kinome Profiling Identifies Druggable Targets for Novel Human Cytomegalovirus (HCMV) Antivirals. Mol Cell Proteomics 16:S263-S276
Jensen, Kara; Dela Pena-Ponce, Myra Grace; Piatak Jr, Michael et al. (2017) Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine. Clin Vaccine Immunol 24:

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