This is a proposal for continued support for a multidisciplinary training program in """"""""Experimental Immunology"""""""" at Loyola University Chicago, Stritch School of Medicine. Twelve well-funded faculty members with active research programs in molecular mechanisms of lymphocyte development and activation, cell transformation, virus entry, mucosal immunity, vaccine development and immunologic disorders have been assembled from the Department of Microbiology &Immunology;Cell Biology, Neurobiology &Anatomy;Medicine;Surgery-Burn Shock Trauma;Pathology;and the Oncology Institute. Dr. Katherine Knight, Professor and Chair of the Department of Microbiology &Immunology, is a highly regarded molecular immunologist with extensive academic training experience, and she will be the Training Program Director. A Training Program Committee and two outside consultants will assist Dr. Knight. The Training Program Committee will oversee the program, select pre-doctoral and postdoctoral trainees, and review the progress of the trainees. The outside consultants will provide general programmatic oversight. The pre-doctoral trainees will be primarily selected from the pool of Ph.D. graduate students matriculated through the Department of Microbiology &Immunology or the interdisciplinary Program in Molecular Biology after they have completed their first or second year of study. Trainees will take a Core Curriculum during the 1st semester, comprised of courses in Molecular Biochemistry, Cellular Biology, Systems Biology, and Methods in Biomedical Research. Subsequently, they will take a series of didactic courses including an immunology course and a minimum of one Topics in Immunology course. Students are expected to become knowledgeable in biochemistry, cell biology, molecular genetics, as well as immunology. Strong emphasis is placed on developing both oral and written communication skills. Post-doctoral trainees will receive their training in laboratories of the participating program faculty. All trainees and program faculty are expected to attend the weekly Immunology Journal Club and Immunology Seminars in the Department of Microbiology and Immunology and in the Oncology Institute. A strategy to recruit minority and economically underrepresented individuals is included in the proposal. All members of the program faculty are committed to excellence in both research and teaching.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-QV-I (M2))
Program Officer
Prograis, Lawrence J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Loyola University Chicago
Schools of Medicine
United States
Zip Code
Nidetz, Natalie F; Gallagher, Tom M; Wiethoff, Christopher M (2018) Inhibition of type I interferon responses by adenovirus serotype-dependent Gas6 binding. Virology 515:150-157
Niemeyer, Daniela; Mösbauer, Kirstin; Klein, Eva M et al. (2018) The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species. PLoS Pathog 14:e1007296
Radke, Jay R; Cook, James L (2018) Human adenovirus infections: update and consideration of mechanisms of viral persistence. Curr Opin Infect Dis 31:251-256
O'Brien, Amornrat; Mettelman, Robert C; Volk, Aaron et al. (2018) Characterizing replication kinetics and plaque production of type I feline infectious peritonitis virus in three feline cell lines. Virology 525:1-9
Radke, Jay R; Figueroa, Iris; Routes, John M et al. (2018) PIDD-dependent activation of caspase-2-mediated mitochondrial injury in E1A-induced cellular sensitivity to macrophage nitric oxide-induced apoptosis. Cell Death Discov 4:35
Nelson, Alexander; Cunha, Christina; Nishimura, Michael I et al. (2018) Activated human Foxp3+ regulatory T cells produce membrane-bound TNF. Cytokine 111:454-459
Clasman, Jozlyn R; Báez-Santos, Yahira M; Mettelman, Robert C et al. (2017) X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design. Sci Rep 7:40292
Radke, Jay R; Cook, James L (2017) Expression of adenoviral E1A throws the PIDD switch. Cell Death Dis 8:e2527
Paynich, Mallory L; Jones-Burrage, Sara E; Knight, Katherine L (2017) Exopolysaccharide from Bacillus subtilis Induces Anti-Inflammatory M2 Macrophages That Prevent T Cell-Mediated Disease. J Immunol 198:2689-2698
Grayczyk, James P; Harvey, Cameron J; Laczkovich, Irina et al. (2017) A Lipoylated Metabolic Protein Released by Staphylococcus aureus Suppresses Macrophage Activation. Cell Host Microbe 22:678-687.e9

Showing the most recent 10 out of 62 publications