This application seeks continued support for a Training Program in Molecular Mechanisms of Microbial Pathogenesis (MMMP) at the University of Michigan. Support for both pre-doctoral and post-doctoral trainees is requested. In the MMMP Ph.D. training program, students select thesis advisors from among a number of trainers in different departments whose research covers broad aspects of infection and immunity. Trainers include bacteriologists, virologists, immunologists, cell biologists and biochemists, all of whom use a range of tools to study microbial pathogenesis and the host response. The training program includes an interdisciplinary curriculum covering basic topics such as biochemistry, genetics and cell biology, and more specialized topics in bacterial and viral pathogenesis, pathology, and immunology. In addition, a research seminar course and an MMMP/Infectious Diseases course that correlates the molecular and cellular mechanisms of pathogenesis with pathophysiology and symptomology of infectious disease are designed to complement the research component of the training. Ph.D. Trainees are recruited to Michigan through the Program in Biomedical Sciences (PIBS). PIBS combines recruiting and first year graduate school experiences for Ph.D. students in 13 programs. Potential MMMP trainees are identified during the PIBS application process. Before the end of their first year at Michigan, MMMP Program trainees will join a comprehensive program of coursework and research leading to a Ph.D. degree in Microbiology and Immunology. Post-doctoral trainees are selected from among those nominated by mentors in the Program. In addition to their research training and participation in the seminar and MMMP/ID course, post-docs have the opportunity to help plan and lecture in courses in the Department of Microbiology. They also participate in a campus-wide Post-doctoral Seminar Series that combines scientific and career planning presentations.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Garges, Susan
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University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
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McGovern, Olivia L; Rivera-Cuevas, Yolanda; Kannan, Geetha et al. (2018) Intersection of endocytic and exocytic systems in Toxoplasma gondii. Traffic 19:336-353
Hannigan, Geoffrey D; Duhaime, Melissa B; Ruffin 4th, Mack T et al. (2018) Diagnostic Potential and Interactive Dynamics of the Colorectal Cancer Virome. MBio 9:
Yarzabek, Brogan; Zaitouna, Anita J; Olson, Eli et al. (2018) Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity. Elife 7:
Wong, Amanda O; Marthi, Matangi; Mendel, Zachary I et al. (2018) Renitence vacuoles facilitate protection against phagolysosomal damage in activated macrophages. Mol Biol Cell 29:657-668
Schultz, Aric J; Carruthers, Vern B (2018) Toxoplasma gondii LCAT Primarily Contributes to Tachyzoite Egress. mSphere 3:
Peck, Kayla M; Lauring, Adam S (2018) Complexities of Viral Mutation Rates. J Virol 92:
Wang, Charles Y; Patel, Nisha; Wholey, Wei-Yun et al. (2018) ABC transporter content diversity in Streptococcus pneumoniae impacts competence regulation and bacteriocin production. Proc Natl Acad Sci U S A 115:E5776-E5785
Hill, David R; Huang, Sha; Nagy, Melinda S et al. (2017) Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium. Elife 6:
Di Cristina, Manlio; Dou, Zhicheng; Lunghi, Matteo et al. (2017) Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection. Nat Microbiol 2:17096
Johnson, Jeremiah G; DiRita, Victor J (2017) Generation and Screening of an Insertion Sequencing-Compatible Mutant Library of Campylobacter jejuni. Methods Mol Biol 1512:257-272

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