The Mechanism of Virus-Host Interactions Training Grant is a multidisciplinary training program designed to train and educate pre-doctoral and post-doctoral trainees in the broad discipline of Virology. This proposal requests continued support for the Virology training program. The faculty is derived from two research institutions, the Mount Sinai School of Medicine (MSSM) and the NYU School of Medicine (NYUSM). The research training emphasis is directed toward teaching pre-doctoral and post-doctoral trainees the theory and experimental approaches required for independent scientific investigations. Students learn the molecular mechanisms involved in virus replication and host responses to viral infections. Research training areas also include novel approaches for antiviral strategies and vaccine development against medically relevant viruses. Our trainees are highly successful in attaining independent research positions, peer-reviewed publications, and extramural research funding. Accordingly, six pre-doctoral and six post-doctoral positions are requested.
The specific aim of the program is to recruit and provide rigorous training to high caliber students and fellows. The continued support of this program will aid trainees in all phases of their development including understanding scientific method, interpretation of results, presentation of data and conclusions, research ethics, and career guidance. By combining the strengths of an outstanding group of virologists, we have created a world-class virology training program. This program is built upon existing collaborations, including research grants, and joint publications between faculty members at MSSM and NYUSM. Accordingly, our collaborative training effort has """"""""added value"""""""" over single institution or individual based initiatives. The program faculty consists of twenty-eight outstanding virologists who use a diverse array of experimental strategies to study the molecular, cellular, biochemical and immunological interactions of viruses with their hosts.

Public Health Relevance

The Mechanism of Virus-Host Interactions Training Grant is vital to the development of the next generation of virologists. These trainees will be leaders in the field of Virology developing strategies to prevent and limit virus pathogenesis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI007647-11
Application #
7944451
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2000-08-01
Project End
2015-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
11
Fiscal Year
2010
Total Cost
$489,067
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
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Chacko, Kieran I; Sullivan, Mitchell J; Beckford, Colleen et al. (2018) Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia. Antimicrob Agents Chemother 62:
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Vink, Elizabeth I; Smiley, James R; Mohr, Ian (2017) Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress. J Virol 91:
Bardina, Susana V; Bunduc, Paul; Tripathi, Shashank et al. (2017) Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. Science 356:175-180
Duehr, James; Wohlbold, Teddy John; Oestereich, Lisa et al. (2017) Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model. J Virol 91:

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