The Molecular Basis of Infectious Disease (MBID) research training program is centered on 16 faculty mentors from three Houston educational institutions: the University, of Texas Health Science Center at Houston, Baylor College of Medicine, and the Texas A&M University Institute for Biosciences and Technology. In this renewal application, continued training support is requested for three Ph.D. students and eight undergraduate summer research students. The overall purpose of the MBID training program is to provide trainees 1) an optimal environment for training new scientists in the latest concepts and techniques in microbiological research;2) a better understanding of current challenges in clinical infectious diseases;and 3) the knowledge and tools to 'bridge the gap'between basic research and clinical applications. The basis of this training grant is the Molecular Basis of Infectious Disease group, which was first formed in 1996. MBID has developed into highly interactive group of over 400 faculty, postdoctoral fellows, graduate students, and staff from the Houston area whose primary interest is in the molecular pathogenesis of bacterial infections. The 16 faculty members that form the core of this training grant have a record of high research productivity and extensive collaborations. They have mentored 178 predoctoral and postdoctoral trainees during the past ten years, and currently are mentoring 22 Ph.D. students and 25 postdoctoral fellows. The training program is based on a strong core curriculum, intensive and interactive research experiences, monthly MBID meetings, annual retreats, weekly seminars and journal clubs, and training in translational research and clinical infectious diseases. A summer research program has been established to aid in the recruitment of promising undergraduate students (and in particular underrepresented minority [URM] trainees) into careers in infectious disease research. During the initial grant period, 3 of 7 predoctoral trainees and 10 of 31 summer undergraduate trainees were URM students, thus promising continued success in this objective during the coming grant period.

Public Health Relevance

The major goal of this ongoing, successful training grant is to provide microbiology trainees additional knowledge in clinical infectious diseases and translational research, thereby directing research toward the more rapid resolution of important infectious disease problems. In addition, the program will continue to recruit highly qualified underrepresented minority students, increasing the proportion of underrepresented minority scientists performing research at the cutting edge of the microbiology/infectious disease interface.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Health Science Center Houston
Schools of Medicine
United States
Zip Code
Oyaro, Micah O; Plants-Paris, Kimberly; Bishoff, Dayna et al. (2018) High rate of Clostridium difficile among young adults presenting with diarrhea at two hospitals in Kenya. Int J Infect Dis 74:24-28
Okyere, Ama; Bishoff, Dayna; Oyaro, Micah O et al. (2018) Analysis of Fish Commonly Sold in Local Supermarkets Reveals the Presence of Pathogenic and Multidrug-Resistant Bacterial Communities. Microbiol Insights 11:1178636118786925
Hunter, Robert L; Actor, Jefrey K; Hwang, Shen-An et al. (2018) Pathogenesis and Animal Models of Post-Primary (Bronchogenic) Tuberculosis, A Review. Pathogens 7:
Darkoh, Charles; Deaton, Magdalena; DuPont, Herbert L (2017) Nonantimicrobial drug targets for Clostridium difficile infections. Future Microbiol 12:975-985
Darkoh, Charles; DuPont, Herbert L (2017) The accessory gene regulator-1 as a therapeutic target for C. difficile infections. Expert Opin Ther Targets 21:451-453
Vesely, Elisa M; Williams, Robert B; Konopka, James B et al. (2017) N-Acetylglucosamine Metabolism Promotes Survival of Candida albicans in the Phagosome. mSphere 2:
Whitaker, Neal; Berry, Trista M; Rosenthal, Nathan et al. (2016) Chimeric Coupling Proteins Mediate Transfer of Heterologous Type IV Effectors through the Escherichia coli pKM101-Encoded Conjugation Machine. J Bacteriol 198:2701-18
Danhof, Heather A; Vylkova, Slavena; Vesely, Elisa M et al. (2016) Robust Extracellular pH Modulation by Candida albicans during Growth in Carboxylic Acids. MBio 7:
Stojanoski, Vlatko; Adamski, Carolyn J; Hu, Liya et al. (2016) Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine ?-Lactamases by Relieving Steric Strain. Biochemistry 55:2479-90
Stojanoski, Vlatko; Sankaran, Banumathi; Prasad, B V Venkataram et al. (2016) Structure of the catalytic domain of the colistin resistance enzyme MCR-1. BMC Biol 14:81

Showing the most recent 10 out of 42 publications