? This continuation of an established program emphasizes the techniques and concepts of cellular and molecular biology, genetics and chemistry applied to fundamental studies of immunology and bone biology in rheumatic and autoimmune diseases. The faculty are highly competent in research and training in: the immune response in mice and humans involving T cells, B cells, dendritic cells, eosinophils and mast cells including: regulation of their cytokines, genetic programs, gene rearrangement mechanisms, antigen presentation, T cell receptor recognition, adhesion and homing, cell biology, inhibitory and activating receptors, factors influencing autoantibody production, and lipid inflammatory mediators. Studies on bone and cartilage include: proteoglycans, the adverse effects of inflammatory processes on the skeletal bone of joints and mechanisms of osteoclast-mediated bone resorption, collagen structure, gene therapy and tissue engineering. Human and animal (mouse) studies of arthritis, synoviocytes and synovial biology and various autoimmune disease models in mice including gene therapy for arthritis, the development of the rheumatoid pannus, the role of leukocyte subsets, cytokines, adhesion molecules and inflammatory mediators in arthritis are studied. Other research in humans includes the epidemiology and risk factors involved in the development and outcomes of rheumatic diseases and their therapeutics and management. While the primary strength of the program resides in the direct and individual nature of the interaction in the laboratory between each fellow and the responsible faculty member(s), substantial didactic experiences and the medical school environment supplement training. Support is requested for 6 postdoctoral trainees having either an M.D., or Ph.D., or both, as well as for 1 predoctoral (Ph.D candidate) trainee. ? ?

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
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Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Gretz, Elizabeth
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Brigham and Women's Hospital
United States
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Sparks, Jeffrey A; Barbhaiya, Medha; Tedeschi, Sara K et al. (2018) Inflammatory dietary pattern and risk of developing rheumatoid arthritis in women. Clin Rheumatol :
Tedeschi, Sara K; Bathon, Joan M; Giles, Jon T et al. (2018) Relationship Between Fish Consumption and Disease Activity in Rheumatoid Arthritis. Arthritis Care Res (Hoboken) 70:327-332
LaMarche, Nelson M; Kohlgruber, Ayano C; Brenner, Michael B (2018) Innate T Cells Govern Adipose Tissue Biology. J Immunol 201:1827-1834
Sparks, Jeffrey A; Chang, Shun-Chiao; Nguyen, Uyen-Sa D T et al. (2018) Smoking Behavior Changes in the Early Rheumatoid Arthritis Period and Risk of Mortality During Thirty-Six Years of Prospective Followup. Arthritis Care Res (Hoboken) 70:19-29
Sparks, Jeffrey A; Chang, Shun-Chiao; Nguyen, Uyen-Sa et al. (2018) Weight Change During the Early Rheumatoid Arthritis Period and Risk of Subsequent Mortality in Women With Rheumatoid Arthritis and Matched Comparators. Arthritis Rheumatol 70:18-29
Tedeschi, Sara K; Cui, Jing; Arkema, Elizabeth V et al. (2017) Elevated BMI and antibodies to citrullinated proteins interact to increase rheumatoid arthritis risk and shorten time to diagnosis: A nested case-control study of women in the Nurses' Health Studies. Semin Arthritis Rheum 46:692-698
Rao, Deepak A; Gurish, Michael F; Marshall, Jennifer L et al. (2017) Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature 542:110-114
Barbhaiya, Medha; Lu, Bing; Sparks, Jeffrey A et al. (2017) Influence of Alcohol Consumption on the Risk of Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts. Arthritis Care Res (Hoboken) 69:384-392
Tedeschi, Sara K; Stone, Richard M; Helfgott, Simon M (2017) Calcium Pyrophosphate Crystal Inflammatory Arthritis (Pseudogout) with Myelodysplastic Syndrome: A New Paraneoplastic Syndrome? J Rheumatol 44:1101-1102
Tedeschi, Sara K; Guan, Hongshu; Fine, Alexander et al. (2016) Organ-specific systemic lupus erythematosus activity during pregnancy is associated with adverse pregnancy outcomes. Clin Rheumatol 35:1725-32

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