The muscle community at the University of Pennsylvania has established an outstanding training program in Muscle Biology and Muscle Disease, supported in part by the T32 mechanism. Members of the Penn community are known world-wide for excellence in muscle research, and this program facilitates collaborative training opportunities for predoctoral students and postdoctoral fellows. Our training program enables trainees to work in laboratories directed by principal investigators who are leaders in the study of the cell biology, genetics, physiology, and/or pathology of muscle. Although the range of interests and expertise of the trainers on this grant is broad, the training is focused on elucidating the mechanisms of muscle function and disease. The program is designed to take advantage of the highly collaborative nature of the faculty, thus providing the trainees with the opportunity to integrate molecular and clinical aspects of muscle biology into their research. Trainees will also take advantage of our intimate connections with the Wellstone Muscular Dystrophy Cooperative Research Center training and education core based at Penn. Through this core, our trainees will receive education in the physiological and clinical aspects of muscular dystrophy. This training diversity provides an unparalleled training environment in the area of muscle biology. This is evidenced by the many prominent scientists around the world who have trained in this field at the University of Pennsylvania.

Public Health Relevance

The muscle community at the University of Pennsylvania has established an outstanding training program in Muscle Biology and Muscle Disease, supported in part by the T32 mechanism. Members of the Penn community are known world-wide for excellence in muscle research, and this program facilitates collaborative training opportunities for predoctoral students and postdoctoral fellows. Our training program enables trainees to work in laboratories directed by principal investigators who are leaders in the study of the cell biology, genetics, physiology, and/or pathology of muscle.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR053461-10
Application #
8846474
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Boyce, Amanda T
Project Start
2006-05-01
Project End
2016-04-30
Budget Start
2015-05-01
Budget End
2016-04-30
Support Year
10
Fiscal Year
2015
Total Cost
$233,356
Indirect Cost
$17,181
Name
University of Pennsylvania
Department
Physiology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Chen, Christina Yingxian; Caporizzo, Matthew A; Bedi, Kenneth et al. (2018) Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. Nat Med 24:1225-1233
McIntosh, Betsy B; Pyrpassopoulos, Serapion; Holzbaur, Erika L F et al. (2018) Opposing Kinesin and Myosin-I Motors Drive Membrane Deformation and Tubulation along Engineered Cytoskeletal Networks. Curr Biol 28:236-248.e5
Gribble, Katherine D; Walker, Lauren J; Saint-Amant, Louis et al. (2018) The synaptic receptor Lrp4 promotes peripheral nerve regeneration. Nat Commun 9:2389
Huegel, Julianne; Choi, Daniel S; Nuss, Courtney A et al. (2018) Effects of pulsed electromagnetic field therapy at different frequencies and durations on rotator cuff tendon-to-bone healing in a rat model. J Shoulder Elbow Surg 27:553-560
Warejko, Jillian K; Tan, Weizhen; Daga, Ankana et al. (2018) Whole Exome Sequencing of Patients with Steroid-Resistant Nephrotic Syndrome. Clin J Am Soc Nephrol 13:53-62
Robinson, Kelsey A; Sun, Mei; Barnum, Carrie E et al. (2017) Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons. Matrix Biol 64:81-93
Johnston, Jessica M; Connizzo, Brianne K; Shetye, Snehal S et al. (2017) Collagen V haploinsufficiency in a murine model of classic Ehlers-Danlos syndrome is associated with deficient structural and mechanical healing in tendons. J Orthop Res 35:2707-2715
Huegel, Julianne; Kim, Dong Hwa; Cirone, James M et al. (2017) Autologous tendon-derived cell-seeded nanofibrous scaffolds improve rotator cuff repair in an age-dependent fashion. J Orthop Res 35:1250-1257
Song, Yafeng; Rosenblum, Shira T; Morales, Leon et al. (2017) Suite of clinically relevant functional assays to address therapeutic efficacy and disease mechanism in the dystrophicmdxmouse. J Appl Physiol (1985) 122:593-602
Szczesny, Spencer E; Driscoll, Tristan P; Tseng, Hsiao-Yun et al. (2017) Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells. ACS Biomater Sci Eng 3:2869-2876

Showing the most recent 10 out of 63 publications