The faculty of two institutions, Weill Medical College and Sloan-Kettering Institute, are requesting funds to support a collaborative training program in basic research in the area of cancer pharmacology. The collaboration consists of an integrated set of training activities for Ph.D. students and postdoctoral fellows. The strength and diversity of the 15 faculty provide opportunities for research in a variety of different areas, such as the development of new cancer therapeutic agents (e.g. through organic synthesis, monoclonal antibody technology, differentiation therapy, and the screening of new compounds), and the analysis of molecular mechanisms by which some drugs cause apoptosis. Research on the control of side effects generated from current treatment modalities [eg. the use of growth factors such as G-CSF to reduce complications associated with bone marrow toxicity] is also a strength. Strategies for overcoming drug resistance are also being developed. Additionally, research concerning the mechanisms by which dioxin and environmental pollutants cause cancer is a part of the training program. The research includes basic mechanistic studies of the molecular actions of drugs used in cancer treatment and cancer prevention, and research leading to more clinical endpoints. The graduate Ph.D. program consists of course work and three lab rotations, followed by an admission to candidacy exam and thesis research. A graduate course in Cancer Pharmacology, initiated ten years ago, is part of this program and represents a commitment of the faculty to the training of students in this area. This training program sponsors a separate seminar series devoted to the area of cancer pharmacology and therapeutics to expose trainees to the research in this area, and students and fellows present their research at the annual two-day Pharmacology Program retreat. Fellows attend a weekly journal club, take courses in cancer pharmacology, and present a formal seminar in the cancer pharmacology seminar series. It is expected that this program will provide students and fellows with a broader understanding of the interrelationships between research on the basic mechanisms of drug action and drug development and clinical issues so that both clinicians and basic scientists will be better prepared to carry out research to prevent or treat cancer. Our request for continued NIH support of a training program in Cancer Pharmacology builds on major commitments of the participating institutions to the enhancement of research in this area. The faculty of this training program are members of the joint WMC/SKI graduate program, with a total of 28 Pharmacology Program faculty. Thus, this faculty represents a cohesive, interactive group of individuals who share a common interest in research and training in the area of cancer pharmacology. ? ?

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
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Study Section
Subcommittee G - Education (NCI)
Program Officer
Eckstein, David J
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Weill Medical College of Cornell University
Schools of Medicine
New York
United States
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Guney, Tezcan; Wenderski, Todd A; Boudreau, Matthew W et al. (2018) Synthesis of Benzannulated Medium-ring Lactams via a Tandem Oxidative Dearomatization-Ring Expansion Reaction. Chemistry 24:13150-13157
Trasino, Steven E; Tang, Xiao-Han; Shevchuk, Maria M et al. (2018) Amelioration of Diabetic Nephropathy Using a Retinoic Acid Receptor ?2 Agonist. J Pharmacol Exp Ther 367:82-94
Patil, Deepak P; Pickering, Brian F; Jaffrey, Samie R (2018) Reading m6A in the Transcriptome: m6A-Binding Proteins. Trends Cell Biol 28:113-127
Quintero, Cynthia M; Laursen, Kristian B; Mongan, Nigel P et al. (2018) CARM1 (PRMT4) Acts as a Transcriptional Coactivator during Retinoic Acid-Induced Embryonic Stem Cell Differentiation. J Mol Biol 430:4168-4182
Verano, Alyssa L; Tan, Derek S (2017) Stereocontrolled Synthesis of Spiroketals: An Engine for Chemical and Biological Discovery. Isr J Chem 57:279-291
Budhathoki-Uprety, Januka; Langenbacher, Rachel E; Jena, Prakrit V et al. (2017) A Carbon Nanotube Optical Sensor Reports Nuclear Entry via a Noncanonical Pathway. ACS Nano 11:3875-3882
Grozhik, Anya V; Linder, Bastian; Olarerin-George, Anthony O et al. (2017) Mapping m6A at Individual-Nucleotide Resolution Using Crosslinking and Immunoprecipitation (miCLIP). Methods Mol Biol 1562:55-78
Jena, Prakrit V; Roxbury, Daniel; Galassi, Thomas V et al. (2017) A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux. ACS Nano 11:10689-10703
Jena, Prakrit V; Safaee, Mohammad M; Heller, Daniel A et al. (2017) DNA-Carbon Nanotube Complexation Affinity and Photoluminescence Modulation Are Independent. ACS Appl Mater Interfaces 9:21397-21405
Vu, Ly P; Pickering, Brian F; Cheng, Yuanming et al. (2017) The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med 23:1369-1376

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