This proposed Surgical Oncology Research Training program is designed for high quality interdisciplinary research training for postgraduate M.D.'s in surgical training programs. The two years interdisciplinary research training prepares the trainees for academic research and teaching positions in surgical oncology. Widely advertised, the program will draw highly qualified trainees particularly women and minorities. Research training is accomplished through four categories of experiences: (1) required core curriculum, (2) preceptor-directed laboratory training in one of 5 areas of oncology research, (3) laboratory and clinical research structured interactive seminars, and (4) attendance at scientific meetings and appropriate symposia. All participating faculty preceptors have active, funded laboratories and a broad base of experience in basic oncology research. The Surgical Oncology Training Executive Committee provides administrative guidance to the program director, evaluates program progress and trainee applications, and suggests direction for future programmatic efforts. The Surgical Oncology Research Advisory Committees consist of members from all of the training areas and currently active preceptors. These committees continuously review the trainees' research progress. The primary research training facility is the New York Presbyterian Hospital/Weill Medical College Cornell University. Research and clinical facilities of Weill Medical College Cornell University, The Rockefeller U n iversity, The Memorial Sloan-Kettering Cancer Center, Strang Cancer Prevention Center and The New York Presbyterian Hospital are available to trainees. The Division of Surgical Oncology maintains the research resources necessary to conduct quality research training in a scientifically sound and cost effective manner. By means of this structure, the Department of Surgery is endeavoring to increase the number of young surgical investigators committed to investigative excellence in academic surgical oncology.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA068971-07
Application #
6512787
Study Section
Subcommittee G - Education (NCI)
Program Officer
Eckstein, David J
Project Start
1996-07-10
Project End
2006-04-30
Budget Start
2002-05-22
Budget End
2003-04-30
Support Year
7
Fiscal Year
2002
Total Cost
$202,552
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Surgery
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065
Tsai, Shirling; Hollenbeck, Scott T; Ryer, Evan J et al. (2009) TGF-beta through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation. Am J Physiol Heart Circ Physiol 297:H540-9
Kundi, Rishi; Hollenbeck, Scott T; Yamanouchi, Dai et al. (2009) Arterial gene transfer of the TGF-beta signalling protein Smad3 induces adaptive remodelling following angioplasty: a role for CTGF. Cardiovasc Res 84:326-35
Liu, Bo; Ryer, Evan Joseph; Kundi, Rishi et al. (2007) Protein kinase C-delta regulates migration and proliferation of vascular smooth muscle cells through the extracellular signal-regulated kinase 1/2. J Vasc Surg 45:160-8
Kamiya, Kentaro; Ryer, Evan; Sakakibara, Kenji et al. (2007) Protein kinase C delta activated adhesion regulates vascular smooth muscle cell migration. J Surg Res 141:91-6
Mongan, Nigel P; Martin, Kisha M; Gudas, Lorraine J (2006) The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures. Mol Carcinog 45:887-900
Ryer, Evan J; Hom, R Patrick; Sakakibara, Kenji et al. (2006) PKCdelta is necessary for Smad3 expression and transforming growth factor beta-induced fibronectin synthesis in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 26:780-6
Carothers, Adelaide M; Javid, Sara H; Moran, Amy E et al. (2006) Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility. Exp Cell Res 312:387-400
Ryer, Evan J; Sakakibara, Kenji; Wang, Chunjie et al. (2005) Protein kinase C delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms. J Biol Chem 280:35310-7
Moran, Amy E; Carothers, Adelaide M; Weyant, Michael J et al. (2005) Carnosol inhibits beta-catenin tyrosine phosphorylation and prevents adenoma formation in the C57BL/6J/Min/+ (Min/+) mouse. Cancer Res 65:1097-104
Sakakibara, Kenji; Kubota, Kenji; Worku, Berhane et al. (2005) PDGF-BB regulates p27 expression through ERK-dependent RNA turn-over in vascular smooth muscle cells. J Biol Chem 280:25470-7

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