The goal of this program is to provide physicians-in-training at St. Jude Children's Research Hospital (SJCRH) with in-depth laboratory experiences such that they can successfully pursue careers as physician-scientists in the field of hematology/oncology. Applicants to this program will perform laboratory research with preceptors selected from a faculty of experienced investigators in interrelated disciplines relevant to cancer: hematology/oncology, molecular pharmacology, biochemistry, immunology, experimental hematology, pharmaceutical sciences, developmental neurobiology, genetics, pathology, virology and molecular biology, and tumor cell biology. Each preceptor is supported by extramural grants, has well-equipped laboratory space, and access to specialized Cancer Center Core Grant-supported shared resource laboratories that provide the latest technology for research in cellular and molecular biology. The program will enroll highly qualified M.D.s or M.D./Ph.D.s who have completed a residency in pediatrics or medicine and desire fellowship training in the subspecialty of hematology/oncology. Funds are requested to support two to three years of basic laboratory research training for each trainee; a year of clinical training mandated by subspecialty boards is funded separately using institutional resources. Trainees will be selected by an Advisory Committee which will evaluate the candidate's credentials and commitment to a career in academic medicine. Training will include a focus on often neglected aspects of cancer research: biostatistics; scientific writing; the design, conduct, and interpretation of clinical trials; and ethical issues related to biomedical research. Further training opportunities will be provided through both institutional and departmental workshops, seminars, retreats, poster sessions, and journal clubs. The trainees will meet regularly with the program director, the training grant Advisory Committee, and the preceptor, so that evaluation and advisement is on-going.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA070089-07
Application #
6612732
Study Section
Subcommittee G - Education (NCI)
Program Officer
Gorelic, Lester S
Project Start
1996-06-01
Project End
2007-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
7
Fiscal Year
2003
Total Cost
$354,433
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Abraham, Allistair; Kim, Yoon-Sang; Zhao, Huifen et al. (2016) Increased Engraftment of Human Short Term Repopulating Hematopoietic Cells in NOD/SCID/IL2r?null Mice by Lentiviral Expression of NUP98-HOXA10HD. PLoS One 11:e0147059
Volanakis, Emmanuel J; Boothby, Mark R; Sherr, Charles J (2013) Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemia. Exp Hematol 41:377-86
McGann, Patrick T; Despotovic, Jenny M; Howard, Thad A et al. (2012) A novel laboratory technique demonstrating the influences of RHD zygosity and the RhCcEe phenotype on erythrocyte D antigen expression. Am J Hematol 87:266-71
Shimasaki, Noriko; Fujisaki, Hiroyuki; Cho, Duck et al. (2012) A clinically adaptable method to enhance the cytotoxicity of natural killer cells against B-cell malignancies. Cytotherapy 14:830-40
McGann, Patrick T; Howard, Thad A; Flanagan, Jonathan M et al. (2011) Chromosome damage and repair in children with sickle cell anaemia and long-term hydroxycarbamide exposure. Br J Haematol 154:134-40
McGann, Patrick T; Ware, Russell E (2011) Hydroxyurea for sickle cell anemia: what have we learned and what questions still remain? Curr Opin Hematol 18:158-65
Campbell, Patrick K; Zong, Yang; Yang, Shengping et al. (2011) Identification of a novel, tissue-specific ABCG2 promoter expressed in pediatric acute megakaryoblastic leukemia. Leuk Res 35:1321-9
Cho, Duck; Shook, David R; Shimasaki, Noriko et al. (2010) Cytotoxicity of activated natural killer cells against pediatric solid tumors. Clin Cancer Res 16:3901-9
McDade, Jenny; Aygun, Banu; Ware, Russell E (2010) Brown recluse spider (Loxosceles reclusa) envenomation leading to acute hemolytic anemia in six adolescents. J Pediatr 156:155-7
Johnson, Robert A; Wright, Karen D; Poppleton, Helen et al. (2010) Cross-species genomics matches driver mutations and cell compartments to model ependymoma. Nature 466:632-6

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