Over one million Americans will suffer from cancer every year, and approximately half of them will die from the disease. Despite major efforts to prevent cancer, effective early diagnosis and treatment of non-metastatic disease remains the hallmark of modern effective cancer management. Surgery persists as a major diagnostic and therapeutic modality for the management of cancer, and advances in the technology of surgical technique (such as fiber-optic and radio-nucleotide visualization of normal and diseased tissue and the miniaturization and robotic control of instruments) have contributed to the improved care of the cancer patient. Nonetheless, it is an understanding of the biologic basis of the disease, and the effective diagnostic and therapeutic management of cancer within a multidisciplinary context that will bring the greatest advances over the next decade. In the current era of discovery, the opportunities for the education and training of surgeons in the biologic basis of cancer is unprecedented. The advances in cancer genetics, cell biology and immunology provide important opportunities for basic, translational and clinical studies in cancer research. As the American College of Surgeons Oncology Group has r e l ocated to Duke, an important opportunity to enhance training in translational research for surgeons exists. This opportunity to educate and train future generations of surgical scientists and leaders provided a c o m pelling imperative for this application for a training grant in translational studies in surgical oncology.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Program Officer
Eckstein, David J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Duke University
Schools of Medicine
United States
Zip Code
Maley, Carlo C; Aktipis, Athena; Graham, Trevor A et al. (2017) Classifying the evolutionary and ecological features of neoplasms. Nat Rev Cancer 17:605-619
Beasley, Georgia M; Speicher, Paul; Augustine, Christina K et al. (2015) A multicenter phase I dose escalation trial to evaluate safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using normothermic isolated limb infusion. Ann Surg Oncol 22:287-94
Speicher, Paul J; Meriwether, Claire H; Tyler, Douglas S (2015) Regional therapies for in-transit disease. Surg Oncol Clin N Am 24:309-22
Turley, Ryan S; Tokuhisa, Yoshihiro; Toshimitsu, Hiroaki et al. (2015) Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma. Ann Surg 261:368-77
Jiang, Betty S; Speicher, Paul J; Thomas, Samantha et al. (2015) Quality of life after isolated limb infusion for in-transit melanoma of the extremity. Ann Surg Oncol 22:1694-700
Andersen, Nicholas D; Hanna, Jennifer M; Ganapathi, Asvin M et al. (2014) Insurance status predicts acuity of thoracic aortic operations. J Thorac Cardiovasc Surg 148:2082-6
Jiang, Betty S; Beasley, Georgia M; Speicher, Paul J et al. (2014) Immunotherapy following regional chemotherapy treatment of advanced extremity melanoma. Ann Surg Oncol 21:2525-31
Speicher, Paul J; Beasley, Georgia M; Jiang, Betty et al. (2014) Hypoxia in melanoma: using optical spectroscopy and EF5 to assess tumor oxygenation before and during regional chemotherapy for melanoma. Ann Surg Oncol 21:1435-40
Tokuhisa, Yoshihiro; Lidsky, Michael E; Toshimitsu, Hiroaki et al. (2014) SRC family kinase inhibition as a novel strategy to augment melphalan-based regional chemotherapy of advanced extremity melanoma. Ann Surg Oncol 21:1024-30
Lidsky, Michael E; Speicher, Paul J; Jiang, Betty et al. (2014) Isolated limb infusion as a model to test new agents to treat metastatic melanoma. J Surg Oncol 109:357-65

Showing the most recent 10 out of 43 publications