This application requests a further five years of support for an Institutional National Research Service Award to support multidisciplinary training in drug abuse research. We request support for seven post-doctoral fellows (2-3 MDs and 4-5 PhDs) per year for primary training in (i) genetics (statistical/ quantitative, behavioral or molecular), (ii) neurobiology and molecular biology of substance use disorders, (iii) epidemiology and nosology of drug abuse and its role in the transmission of HIV and infectious diseases. In addition to specialization in a primary discipline, trainees are encouraged to obtain a sufficient familiarity with at least one other focus area to facilitate fruitful cross-disciplinary collaborations in their research careers. The training program will ordinarily be of 3 years duration, reflecting the diverse background of our applicant pool (e.g. psychiatry, infectious diseases, mathematics, chemical engineering, biostatistics, neurobiology, molecular genetics, social work, sociology, anthropology, psychology, economics, neuroscience), or 2 years for those with pertinent research experience. One-year post-doctoral fellowships are also offered for experienced drug abuse researchers seeking training in a new area of drug abuse research (e.g. genetics). Trainees are housed in specially designed post-doctoral offices in the Psychiatry section of the University's Biotechnology Center and in the laboratory facilities of the Clinical Sciences Research Building. The program emphasizes a research apprenticeship model in combination with formal training through didactic courses and individualized tutorials. Major strengths of the program are the expertise of the faculty in genetic, epidemiologic and nosologic, molecular biologic and neurobiologic research on substance use disorders (including HIV-related research), the long tradition of successful research training of individuals from diverse backgrounds, the highly productive research environment (with the preceptors holding a total of 42 federally funded grants), and the access to major ongoing projects and to existing epidemiologic and family data-bases that offer many research possibilities to trainees.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
5T32DA007261-10
Application #
6174657
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Babecki, Beth
Project Start
1991-09-30
Project End
2001-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
10
Fiscal Year
2000
Total Cost
$338,117
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Rosen, Allyson C; Soman, Salil; Bhat, Jyoti et al. (2018) Convergence Analysis of Micro-Lesions (CAML): An approach to mapping of diffuse lesions from carotid revascularization. Neuroimage Clin 18:553-559
Sheahan, Tayler D; Valtcheva, Manouela V; McIlvried, Lisa A et al. (2018) Metabotropic Glutamate Receptor 2/3 (mGluR2/3) Activation Suppresses TRPV1 Sensitization in Mouse, But Not Human, Sensory Neurons. eNeuro 5:
Siegel, Joshua S; Seitzman, Benjamin A; Ramsey, Lenny E et al. (2018) Re-emergence of modular brain networks in stroke recovery. Cortex 101:44-59
Munanairi, Admire; Liu, Xian-Yu; Barry, Devin M et al. (2018) Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice. Cell Rep 23:866-877
Levinson, Cheri A; Sala, Margarita; Fewell, Laura et al. (2018) Meal and snack-time eating disorder cognitions predict eating disorder behaviors and vice versa in a treatment seeking sample: A mobile technology based ecological momentary assessment study. Behav Res Ther 105:36-42
Teitelbaum, A M; Murphy, S E; Akk, G et al. (2018) Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. Pharmacogenomics J 18:136-143
McIlvried, Lisa A; Cruz, J Agustin; Borghesi, Lisa A et al. (2017) Sex-, stress-, and sympathetic post-ganglionic-dependent changes in identity and proportions of immune cells in the dura. Cephalalgia 37:36-48
Gordon, Evan M; Laumann, Timothy O; Gilmore, Adrian W et al. (2017) Precision Functional Mapping of Individual Human Brains. Neuron 95:791-807.e7
Xia, Li; Nygard, Stephanie K; Sobczak, Gabe G et al. (2017) Dorsal-CA1 Hippocampal Neuronal Ensembles Encode Nicotine-Reward Contextual Associations. Cell Rep 19:2143-2156
Brosof, Leigh C; Levinson, Cheri A (2017) Social appearance anxiety and dietary restraint as mediators between perfectionism and binge eating: A six month three wave longitudinal study. Appetite 108:335-342

Showing the most recent 10 out of 83 publications