. BB Princi -.westigator/ProgramDirector(Lest. first. middle): .B, -ne, RobertA. DESCRIPTION.SBte the aplication's broad, %tn cbjectivesandspecifc aims, makingref6encetohebhrelatedness of the pqect.'Dscribe cmiselythe . ' . reseachdesignandmethaisfor actievingUlesegods.Avcid summaries of pstaccomdishmentsandthe use of firstperson. This description ismeanttosrveas a ' succixt aridaccuratedescriptiondthe propxedworkwhen separatedfromtheapplication. lftheapplicationisfinded, this descripfon,as is, will beamepublic ' nfmation.Thefore,cb not inccldewowietary/conldentialnfofmatim DO NOT EXCEED MESPACE RIOVIDED. Oral Infectious Diseases, including dental caries, periodontal diseases, mucosal lesions caused by Candida spp., and infections by herpesvirus and human papilloma virus affectvirtuaIly every human on the planet. Recent epidemiological evidence points to an important connection between oral health, oral infections and life threateningsystemic diseases. In 1998in theUSalone, over $58 billion was expended on dental services, and thevast majority of these expenditureswere duedirectlyto the consequences of Oral Infectious Diseases. The Surgeon General'sReport on Oral Health (2000) dramatically emphasizes the serious and widespread nature of the health problems created by Oral Infectious Diseases, which areparticularly abundant among the poor and underrepresented minorities because of inadequate intervention or lack of access to treatment. Clearly, the most effectivemeans to combatOral Infectious Diseases on a large scaleis to developeffective and economicallyrealistic mechanisms to prevent these diseases in the USand abroad. A thorough working understandingof the molecular basis for the pathogenesis of Oral Infectious agents and the interaction of host cells and the immune systemwith these agents is the foundation for disclosing novel targets for combatingthese infections. Because of huge conceptualand technologicalstridesmade inthe studyof pathogens and host:pathogen interactions, such as whole genome sequencingand DNA microaxray techniques,researchers are no longer limited by many tedious technical hurdles to exploringpathogenesis in extreme molecular detail. However, those individualswho will be in a position to make the most important advancesin ourunderstandingof Oral Infectious Diseases will be those who arenot onlywell trained in the basics of Oral Microbiology and Immunology,but they must be immersed in a training environmentwhere they absorb athorough and completeunderstanding of host:pathogen interactions and how to putto use the most advanced technologies for studying oral infections. The Training Program in Oral Infectious Diseases provides pre- and post-doctoral training for basic and clinical scientistsin a dynamic environment with a long and productive history of training in the Oral Sciences. The interleaving of highly structured didactic requirements with an outstanding training environment and a training facultywith a solid history of educatingbasic and clinical sciences insures excellencein the training of Oral Infectious Diseases researchers. ERFORMANCESITE(S)(organization,city, state) Center for Oral Biology ' 601 Elmwood Avenue Rochester,NY 14642 KEY PERSONEL. See instrudonson Page 11. Usecontinuation pages as neededto providethe requiredinformation inthe format shownbelow. .. , ' Name Organization RoleonProject ,, ' . Burne, RobertA. . Bambara. Robert ' ' Bowen. William Caton.Jack . Cohen, Nicholas Cory-Slechta, Deborah Dewhurst, Stephen ' ' Fay, Philip Haidaris, Constantine Marquis, Robert ' McCance, Dennis Min, Wang .Mosmann,Tim ' Pavelka, Martin ' Phipps, Richard ' Quivey, Robert University of Rochester Program Director, Potential Mentor University of Rochester Potential Mentor University of Rochester Member Int. Adv. Comm., Potential Mentor University of Rochester . Member Int. Adv. Comm. University of Rochester . Member Int. Adv. Comm. . University of Rochester '. Member Int. Adv. Comm. . , , University of Rochester Potential Mentor University of Rochester Potential .Mentor University of Rochester Potential Mentor University of Rochester Potential.Mentor University of Rochester Potential Mentor University of Rochester Potential Mentor . University of Rochester , Potential Mentor . University of Rochester Potential Mentor . University of Rochester Potential Mentor University of Rochester Potential Mentor ' ; PHS398 (Rev. 4/98) Page 2 BB Number pages consecutively at the bottom throughout the application. Do=! use suffixessuchas3a, 3b: ========================================Section End===========================================

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NIDCR Special Grants Review Committee (DSR)
Program Officer
Hardwick, Kevin S
Project Start
Project End
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Fiscal Year
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University of Rochester
Schools of Dentistry
United States
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Galv√£o, L C C; Rosalen, P L; Rivera-Ramos, I et al. (2017) Inactivation of the spxA1 or spxA2 gene of Streptococcus mutans decreases virulence in the rat caries model. Mol Oral Microbiol 32:142-153
Baker, J L; Derr, A M; Faustoferri, R C et al. (2015) Loss of NADH Oxidase Activity in Streptococcus mutans Leads to Rex-Mediated Overcompensation in NAD+ Regeneration by Lactate Dehydrogenase. J Bacteriol 197:3645-57
Faustoferri, R C; Hubbard, C J; Santiago, B et al. (2015) Regulation of fatty acid biosynthesis by the global regulator CcpA and the local regulator FabT in Streptococcus mutans. Mol Oral Microbiol 30:128-46
Kajfasz, Jessica K; Rivera-Ramos, Isamar; Scott-Anne, Kathleen et al. (2015) Transcription of Oxidative Stress Genes Is Directly Activated by SpxA1 and, to a Lesser Extent, by SpxA2 in Streptococcus mutans. J Bacteriol 197:2160-2170
Buckley, Andrew A; Faustoferri, Roberta C; Quivey Jr, Robert G (2014) ?-Phosphoglucomutase contributes to aciduricity in Streptococcus mutans. Microbiology 160:818-27
Baker, J L; Derr, A M; Karuppaiah, K et al. (2014) Streptococcus mutans NADH oxidase lies at the intersection of overlapping regulons controlled by oxygen and NAD+ levels. J Bacteriol 196:2166-77
Santiago, Brendaliz; MacGilvray, Matthew; Faustoferri, Roberta C et al. (2012) The branched-chain amino acid aminotransferase encoded by ilvE is involved in acid tolerance in Streptococcus mutans. J Bacteriol 194:2010-9
Derr, Adam M; Faustoferri, Roberta C; Betzenhauser, Matthew J et al. (2012) Mutation of the NADH oxidase gene (nox) reveals an overlap of the oxygen- and acid-mediated stress responses in Streptococcus mutans. Appl Environ Microbiol 78:1215-27
Gonzalez, Kaisha; Faustoferri, Roberta C; Quivey Jr, Robert G (2012) Role of DNA base excision repair in the mutability and virulence of Streptococcus mutans. Mol Microbiol 85:361-77
Spinelli, Sherry L; Casey, Ann E; Pollock, Stephen J et al. (2010) Platelets and megakaryocytes contain functional nuclear factor-kappaB. Arterioscler Thromb Vasc Biol 30:591-8

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