This is a competing continuation application for the University of Utah's Research Training in Hematology Program, a program established in 1943 by Dr. M.M. Wintrobe. Twenty-four faculty members serve as research preceptors for trainees, and the faculty consists of both physician-scientists and basic scientists from the Departments of Medicine, Biochemistry, Chemistry, Human Genetics, Oncological Sciences, Pathology, and Pediatrics. Research groups participating in the Training Program include the Molecular Regulation of Metal and Heme Metabolism and the Hematopoiesis-Cell Differentiation Group. The special attribute of this multidisciplinary training program is the faculty with which trainees can interact, with both basic and clinical investigators. The unifying element is the common objective to train post-doctoral fellows and graduate students who can conduct studies at the cutting edge of hematologic research. In our program, physician-trainees interact with basic science post-doctoral trainees and graduate students every day, and this interaction promotes an expanded view of hematologic research for both groups of post-doctoral fellows and the graduate students working in the laboratories of the training faculty. A plan is presented to expand the pre-doctoral Training Program by incorporating a newly created University of Utah Med-into-Grad Program. This program is designed to transform basic science graduate education by integrating intensive, clinically-relevant education into pre-doctoral training. The program will permit graduate students to obtain dual degrees, a department-specific Ph.D. degree and a medical school-wide Master of Science in clinical investigation. The application requests support for six pre-doctoral trainees and six post-doctoral fellows (a mixture of physician-trainees and Ph.D. post-doctoral trainees).
Hematology has led medical sciences into an era of enormous advances in the cellular and molecular basis of many diseases. The leading role of hematology is explained, in part, by the ease of access to blood and bone marrow cells. An expanded core of investigators trained in molecular biology and cell physiology is required to exploit new opportunities afforded by advances in technology. The Hematology Research Training Program at the University of Utah is designed to train these investigators.
|Szaniawski, Matthew A; Spivak, Adam M; Cox, James E et al. (2018) SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition. MBio 9:|
|Wallace, Jared A; O'Connell, Ryan M (2017) MicroRNAs and acute myeloid leukemia: therapeutic implications and emerging concepts. Blood 130:1290-1301|
|Fidler, Trevor P; Campbell, Robert A; Funari, Trevor et al. (2017) Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep 20:881-894|
|Nielson, Jason R; Fredrickson, Eric K; Waller, T Cameron et al. (2017) Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria. Mol Cell 68:673-685.e6|
|Bosque, Alberto; Nilson, Kyle A; Macedo, Amanda B et al. (2017) Benzotriazoles Reactivate Latent HIV-1 through Inactivation of STAT5 SUMOylation. Cell Rep 18:1324-1334|
|Fidler, Trevor P; Middleton, Elizabeth A; Rowley, Jesse W et al. (2017) Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arterioscler Thromb Vasc Biol 37:1628-1639|
|Wallace, Jared A; Kagele, Dominique A; Eiring, Anna M et al. (2017) miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response. Blood 129:3074-3086|
|Green, Yangsook Song; Kwon, Sunjong; Christian, Jan L (2016) Expression pattern of bcar3, a downstream target of Gata2, and its binding partner, bcar1, during Xenopus development. Gene Expr Patterns 20:55-62|
|Olson, Kristofor A; Schell, John C; Rutter, Jared (2016) Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies. Trends Biochem Sci 41:219-230|
|Kikani, Chintan K; Wu, Xiaoying; Paul, Litty et al. (2016) Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis. Elife 5:|
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