With NIH support the Washington University faculty has successfully trained individuals for careers in endocrinology and metabolism for 48 years, and conducted an integrated program for training academicians in both Medicine and Pediatrics for 39 years. Thirty-eight graduates of this program have become senior professors and scores more hold junior faculty positions at diverse institutions. The training focus is on diabetes and related disorders, an area with along and productive research history at Washington University. The Training Program is based in the Endocrinology, Metabolism and Lipid Research Division of the Departments of Medicine and Pediatrics. It is closely coordinated with ? the highly relevant research activities of several NIH Centers (Diabetes Research and Training, Mass Spectrometry, Lipid Research and General Clinical Research), program projects (#4), individual R01 research grants (66), and numerous other grants totaling >$36 million in research support. These activities are also supported by the Departments of Pathology, Cell Biology, Biological Chemistry, Genetics, Pharmacology, and Surgery, and by the Division of Bone and Mineral Metabolism. Training is conducted by the Director and 42 Primary and 3 Clinical Faculty, all of whom are actively involved in diabetes-related research ranging from molecular and cellular biology, biochemistry, immunology and genetics to human physiology and pathophysiology. Twenty-five of the faculty hold primary or joint appointments in pre-clinical departments. The trainees and faculty maintain close interactions through journal clubs, research seminars, and trainee conferences. Most trainees hold M.D. (or M.D./Ph.D.) degrees and have completed clinical training in medicine or pediatrics. Their selection is based upon a promising interest in research, academic excellence and evidence of clinical competence and judgment. The major goal of the program is to provide an intensive research experience (generally more than 80% of the time) under direct faculty supervision as the basis for a productive, independent investigative career, although sufficient clinical experience is also provided. The duration of training is three years in most cases. The faculty laboratories are either new or newly renovated and fully equipped for modern biomedical research. Indeed, both the recent expansion and development of these facilities and the recruitment of new faculty in diabetes-related fields are objective evidence of the commitment of Washington University to the support of both basic and clinical diabetes-related research and to the training of new investigators in this important area. ? ?

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZDK1-GRB-R (M3))
Program Officer
Castle, Arthur
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Washington University
Internal Medicine/Medicine
Schools of Medicine
Saint Louis
United States
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Williams, Jesse W; Martel, Catherine; Potteaux, Stephane et al. (2018) Limited Macrophage Positional Dynamics in Progressing or Regressing Murine Atherosclerotic Plaques-Brief Report. Arterioscler Thromb Vasc Biol 38:1702-1710
Chen, Yana; McCommis, Kyle S; Ferguson, Daniel et al. (2018) Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid. Endocrinology 159:609-621
Bao, Yicheng K; Salam, Maamoun; Parks, Deborah et al. (2018) High prevalence of systemic rheumatic diseases in women with type 1 diabetes. J Diabetes Complications 32:737-739
Liss, Kim H H; Lutkewitte, Andrew J; Pietka, Terri et al. (2018) Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans. J Lipid Res 59:1630-1639
Rajagopal, Rithwick; Zhang, Sheng; Wei, Xiaochao et al. (2018) Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision. JCI Insight 3:
Ferguson, Daniel; Blenden, Mitchell; Hutson, Irina et al. (2018) Mouse Embryonic Fibroblasts Protect ob/ob Mice From Obesity and Metabolic Complications. Endocrinology 159:3275-3286
Bauerle, Kevin T; Hutson, Irina; Scheller, Erica L et al. (2018) Glucocorticoid Receptor Signaling Is Not Required for In Vivo Adipogenesis. Endocrinology 159:2050-2061
Hughes, Jing W; Bao, Yicheng K; Salam, Maamoun et al. (2018) Late-Onset T1DM and Older Age Predict Risk of Additional Autoimmune Disease. Diabetes Care :
Semenkovich, Clay F (2017) We Know More Than We Can Tell About Diabetes and Vascular Disease: The 2016 Edwin Bierman Award Lecture. Diabetes 66:1735-1741
Vigueira, Patrick A; McCommis, Kyle S; Hodges, Wesley T et al. (2017) The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Exp Physiol 102:985-999

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