The major components of this program include comprehensive research training under supervision of committed mentors with diverse scientific expertise, incorporation of multidisciplinary approaches to biomedical investigation, well-equipped research environment with aces to state of the art technologies, protection from distracting responsibilities, and formal didactic instruction and enrichment activities. (A) Research Areas and Disciplines: A major strength of this training program is its multidisciplinary nature. This provides ample opportunities of training across disciplines, permitting novel approaches to be applied to complex biomedical problems. Training is offered in cell and molecular biology, structural biology, photobiology, stem cell biology, genetics, genomics, metabolomics and proteomics, autoimmunity and transplantation biology, and in translational research. These disciplines are applied to nine research themes that are relevant to diseases such as diabetes, hypertension, nephritis, vasculitis and polycystic kidney disease. For those trainees opting for clinical research, enrollment in formal instructional courses in the relevant quantitative sciences is mandated. All research trainees are required to complete a revised three- component program in the responsible conduct of research. (B) Level of Training, Background and Numbers of Trainees. In this renewal, we request eight postdoctoral positions, offered to MDs, MD-PhDs or PhDs on an annual basis. In addition, we request support for a one new predoctoral position each year to be offered to an under-represented minority student completing an undergraduate degree or enrolled in graduate or medical school. We also request tuition support for formal instructional courses in the basic sciences required of MDs with no previous training in bench research but who are committed to a basic research track. (C) Training Facilities. Research training is conducted in the laboratories of the research mentors, a collaborative group of established investigators with strong training records and scientific achievements in diverse scientific disciplines. The laboratories collectively occupy 277,700 sq. ft of dedicated research space located mainly at the Massachusetts General Hospital.
The overall objective of the Nephrology Training Program at the Massachusetts General Hospital is to provide our trainees with a strong foundation in basic and translational research, using state of the art technologies to address complex biomedical problems pertaining to the renovascular system. Initially focused on providing experience in molecular and cell biology, the scope of the program is being expanded to also include training in new emerging fields and across scientific disciplines.
|Poyan Mehr, Ali; Tran, Mei T; Ralto, Kenneth M et al. (2018) De novo NAD+ biosynthetic impairment in acute kidney injury in humans. Nat Med 24:1351-1359|
|Lim, Kenneth; Hamano, Takayuki; Thadhani, Ravi (2018) Vitamin D and Calcimimetics in Cardiovascular Disease. Semin Nephrol 38:251-266|
|Nguyen, Hai Dang; Leong, Wan Yee; Li, Weiling et al. (2018) Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes. Cancer Res 78:5363-5374|
|Pang, Paul; Abbott, Molly; Abdi, Malyun et al. (2018) Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function. Nephrol Dial Transplant 33:923-934|
|Kabeche, Lilian; Nguyen, Hai Dang; Buisson, Rémi et al. (2018) A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation. Science 359:108-114|
|Cortazar, Frank B; Pendergraft 3rd, William F; Wenger, Julia et al. (2017) Effect of Continuous B Cell Depletion With Rituximab on Pathogenic Autoantibodies and Total IgG Levels in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Rheumatol 69:1045-1053|
|Olabisi, Opeyemi A; Heneghan, John F (2017) APOL1 Nephrotoxicity: What Does Ion Transport Have to Do With It? Semin Nephrol 37:546-551|
|Tangren, Jessica Sheehan; Powe, Camille E; Ankers, Elizabeth et al. (2017) Pregnancy Outcomes after Clinical Recovery from AKI. J Am Soc Nephrol 28:1566-1574|
|Dehnadi, Abbas; Benedict Cosimi, A; Neal Smith, Rex et al. (2017) Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys. Nat Commun 8:13899|
|Wang, Chia-Yu; Core, Amanda B; Canali, Susanna et al. (2017) Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice. Blood 130:73-83|
Showing the most recent 10 out of 78 publications