This training grant has functioned for two decades and the results have revolutionized the treatment of many major urological diseases including the research of two former residents, Drs. Herbert Lepor and Ellen Shapiro whose Alpha-1-andrenergic research studies on BPH were followed up by clinical studies of a urology resident, Craig Peters, who demonstrated the effects of androgens on BPH. This resulted in BPH urinary obstruction being treated medically thus resulting in a dramatic decrease in the number of BPH urinary obstruction surgeries. In 1992, a resident, Arthur Burnett, reported in Science on the role of nitric oxide in erections. This is now the key background concept for the subsequent development of treatments of erectile dysfunction. Three former trainees (Nelson, De Marzo, and Isaacs) reported (NEJM, 2003) on a new model for the etiology of abnormal prostate growth involving inflammation and DNA methylation. Current lab focus is on biomarkers, drugs that protect nerves, telesurgery, robot design , quantitative morphology, DNA organization and telomeres, genetic vaccines, new RNA markers and probes, urine markers, and developmental biology. The last three major urological chairmen appointed in the U. S. were trained, in part, in this lab program - Partin/Johns Hopkins;Schlegel/Cornell Univ.;Benson/Columbia Univ . Seven Ph.D.'s are now urological research directors. This grant requests support for five research trainees that are composed of three types: Post Resident Physician Scientists who have completed residency training and spend an additional one to two years in research;2.) Medical Urological Research Fellows who will spend one or more years in full-time research;3.) Postdoctoral Research Fellows - Ph.D.s or M.D., Ph.D.s in full-time research who have already completed graduate training at a basic science discipline;4.) Predoctoral Ph.D. Graduate Program Students carrying out their thesis in the urology labs who are not funded by this grant but who form part of the interacting research training environment. Each of these four components of our Urological Training Program contributes to the success of each part. The ability to understand the biology of the disease and to work on human pathological material with the application of precise molecular and pathological techniques that are now forthcoming provide a rich environment for training future research leaders to study devastating medical problems within the field of urology.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rankin, Tracy L
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Johns Hopkins University
Schools of Medicine
United States
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Hurley, Paula J; Sundi, Debasish; Shinder, Brian et al. (2016) Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer. Clin Cancer Res 22:448-58
Sundi, Debasish; Faisal, Farzana A; Trock, Bruce J et al. (2015) Reclassification rates are higher among African American men than Caucasians on active surveillance. Urology 85:155-60
Vander Griend, Donald J; Litvinov, Ivan V; Isaacs, John T (2014) Conversion of androgen receptor signaling from a growth suppressor in normal prostate epithelial cells to an oncogene in prostate cancer cells involves a gain of function in c-Myc regulation. Int J Biol Sci 10:627-42
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Sundi, Debasish; Wang, Vinson; Pierorazio, Phillip M et al. (2014) Identification of men with the highest risk of early disease recurrence after radical prostatectomy. Prostate 74:628-36
Sundi, Debasish; Ross, Ashley E; Humphreys, Elizabeth B et al. (2013) African American men with very low-risk prostate cancer exhibit adverse oncologic outcomes after radical prostatectomy: should active surveillance still be an option for them? J Clin Oncol 31:2991-7
Anusionwu, Ifeanyichukwu I; Wright, E James (2013) Indications for revision of artificial urinary sphincter and modifiable risk factors for device-related morbidity. Neurourol Urodyn 32:63-5
Suson, Kristina D; Sponseller, Paul D; Gearhart, John P (2013) Bony abnormalities in classic bladder exstrophy: the urologist's perspective. J Pediatr Urol 9:112-22

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