This proposal seeks continuation of support for Cedars-Sinai's, """"""""Training Program in Endocrinology, Diabetes, and Metabolism"""""""". Consistent with the history of this program our goal is to train scientists to study thyroid, reproductive endocrinology, diabetes/metabolism, endocrine oncology, endocrine hypertension, and neuroendocrinology. Fifteen faculty members, from seven departments/institutes, including our Director, Shlomo Melmed, MD, represent these areas of research. Our faculty mentors are a strength of this program with over $33,796,659 million dollars in funding and 640 peer reviewed publications with trainees over the last ten years. This type of productivity has led to our fellow funded by this T32 publishing 134 peer- reviewed articles and 6 fellows obtaining NIH extramural funding since the inception of our training grant. We will continue this success with program improvements such as modified areas of research, improved program assessment and tracking, increased trainee recruitment (including underrepresented minorities), collaboration with Sanford- Burnham Medical Research Institute and addition of eight new faculty. A major faculty recruitment is Dr. Richard Bergman, an expert in obesity and diabetes and pioneer of the """"""""minimal model"""""""". We are requesting funding support for four postdoctoral positions.

Public Health Relevance

Endocrinology related diseases are a major area of health concern for today's society. Cedars-Sinai's, Training Program in Endocrinology, Diabetes, and Metabolism addresses the specialized training of scientist in several areas of endocrinology research including but not limited to diabetes, obesity, cancer, and high blood pressure.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007770-12
Application #
8479343
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
1999-08-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
12
Fiscal Year
2013
Total Cost
$194,311
Indirect Cost
$14,393
Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048
Araki, Takako; Liu, Ning-Ai (2018) Cell Cycle Regulators and Lineage-Specific Therapeutic Targets for Cushing Disease. Front Endocrinol (Lausanne) 9:444
Yamamoto, Masaaki; Ben-Shlomo, Anat; Kameda, Hiraku et al. (2018) Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function. JCI Insight 3:
Gonzalez, Tania L; Sun, Tianyanxin; Koeppel, Alexander F et al. (2018) Sex differences in the late first trimester human placenta transcriptome. Biol Sex Differ 9:4
Ehrhardt, Nicole; Doche, Michael E; Chen, Shuang et al. (2017) Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis. Hum Mol Genet 26:2719-2731
Recouvreux, M Victoria; Wu, J Boyang; Gao, Allen C et al. (2017) Androgen Receptor Regulation of Local Growth Hormone in Prostate Cancer Cells. Endocrinology 158:2255-2268
Chesnokova, Vera; Zonis, Svetlana; Zhou, Cuiqi et al. (2016) Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A 113:E3250-9
Melmed, Shlomo (2016) Pituitary Medicine From Discovery to Patient-Focused Outcomes. J Clin Endocrinol Metab 101:769-77
Smith, Bethany N; Bhowmick, Neil A (2016) Role of EMT in Metastasis and Therapy Resistance. J Clin Med 5:
Araki, Takako; Liu, Ning-Ai; Tone, Yukiko et al. (2016) E2F1-mediated human POMC expression in ectopic Cushing's syndrome. Endocr Relat Cancer 23:857-870
Shah, Kandarp H; Shi, Peng; Giani, Jorge F et al. (2015) Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension. Circ Res 117:858-69

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