Benign urological diseases create a substantial burden on the US healthcare system because of their prevalence, impact on quality of life and cost. Collectively, congenital genitourinary anomalies, kidney stones, urinary incontinence, erectile dysfunction, lower urinary tract symptoms, benign prostatic hyperplasia, pelvic pain and urethral strictures affect millions of persons and account for over 3.6 billion dollars in annual healthcare expenditures.1 Urinary tract infections contribute an additional 2.47 billion dollars in direct costs. Unmeasured costs related to over-the counter-incontinence products, prescription drugs, and lost productivity due to kidney stones and UTI are exponentially greater. Diabetes, obesity and inactivity, injury, and nutritional choices amplify the prevalence and severity of thes urological disorders. The daunting challenges to effective prevention, control, and treatment require new research paradigms and innovative solutions that harness advances in technology, information and thinking. Thus, this competing renewal creates a multidisciplinary research training program for M.D. and Ph.D. postdoctoral research fellows that addresses benign urological diseases across the entire lifespan. Our long term goal is to train the next generation of urological researchers who can substantiate the first goal of Healthy People 2020, namely to attain high quality longer lives. Two training slots per year will be tailored to our main constituents: M.D. and Ph.D. trainees seeking a two- year fellowship after completion of graduate medical education or graduate school respectively. These trainees will be recruited from our own fellow candidates in Pediatric Urology and Trauma and Reconstruction; from other clinical Departments at UW including Medicine, OB/GYN, Pathology and Radiology; from the graduate programs of our mentors; and from peer organizations nationally. Our program emphasizes robust research projects over methodology. Innovation in research will be central to the program and will be catalyzed by the interplay of mentors from basic science, epidemiology, engineering and patient oriented research disciplines. Each trainee will be linked to an experienced NIH funded research mentor and a practicing urologist with relevant clinical expertise. Multidisciplinary Training in Benign Urology leverages strengths at the University of Washington including a longstanding tradition of urological education, cutting edge collaborative learning environments, and world-class researchers within and outside of traditional areas of urological research.

Public Health Relevance

Multidisciplinary Training in Benign Urology leverages strengths at the University of Washington to address the critical need for Training in benign urological diseases including congenital genitourinary disorders, kidney stones, urinary incontinence, erectile dysfunction, benign prostatic hyperplasia, pelvic pain and urinary tract infections. Collectively these disorders account for over 6 billion dollars in annual health care costs, and their burden will be amplified by diabetes, obesity, aging and inactivity. Our training program creates small multidisciplinary teams that include M.D. and Ph.D. researchers from outside the field, linked to a practicing urologist to focus from the outset on the potential clinial impact of each project.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Rankin, Tracy L
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University of Washington
Schools of Medicine
United States
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Tessler, Robert A; Lyons, Vivian H; Hagedorn, Judith C et al. (2018) Transfer and nontransfer patients in isolated low-grade blunt pediatric solid organ injury: Implications for regionalized trauma systems. J Trauma Acute Care Surg 84:606-612
Palmer, Melody R; Holt, Sarah K; Sarma, Aruna V et al. (2017) Longitudinal Patterns of Occurrence and Remission of Erectile Dysfunction in Men With Type 1 Diabetes. J Sex Med 14:1187-1194
Maxwell, Adam D; Yuldashev, Petr V; Kreider, Wayne et al. (2017) A Prototype Therapy System for Transcutaneous Application of Boiling Histotripsy. IEEE Trans Ultrason Ferroelectr Freq Control 64:1542-1557
Maxwell, Adam D; Cunitz, Bryan W; Kreider, Wayne et al. (2015) Fragmentation of urinary calculi in vitro by burst wave lithotripsy. J Urol 193:338-44
Khokhlova, Vera A; Fowlkes, J Brian; Roberts, William W et al. (2015) Histotripsy methods in mechanical disintegration of tissue: towards clinical applications. Int J Hyperthermia 31:145-62
Maxwell, Adam D; Hsi, Ryan S; Bailey, Michael R et al. (2014) Noninvasive ureterocele puncture using pulsed focused ultrasound: an in vitro study. J Endourol 28:342-6
Hotaling, James M; Waggott, Daryl R; Goldberg, Jack et al. (2012) Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort. J Urol 188:514-20
Wessells, Hunter; Sullivan, Chris J; Tsubota, Yoshiaki et al. (2009) Transcriptional profiling of human cavernosal endothelial cells reveals distinctive cell adhesion phenotype and role for claudin 11 in vascular barrier function. Physiol Genomics 39:100-8
Delostrinos, Catherine F; Hudson, Amber E; Feng, Waldo C et al. (2006) The C-terminal Ca2+-binding domain of SPARC confers anti-spreading activity to human urothelial cells. J Cell Physiol 206:211-20
Sullivan, Chris J; Teal, Thomas H; Luttrell, Ian P et al. (2005) Microarray analysis reveals novel gene expression changes associated with erectile dysfunction in diabetic rats. Physiol Genomics 23:192-205

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