This application is for the second renewal of the Institutional Training Program (T32) in Pediatric Gastroenterology, Hepatology and Nutrition at the University of Colorado Denver (UCD) and Children's Hospital Colorado at the Anschutz's Medical Campus in Aurora, Colorado. The overall goal of this program is to provide post-doctoral trainees with an exceptional supervised training experience to allow them to develop or enhance their research skills and knowledge in preparation for a pediatric gastroenterology or hepatology related research career. The underlying rationale for this program is to take advantage of the strong physical and scientific synergies provided at the Anschutz Medical Campus, an outstanding committed and experienced research faculty, and a large pool of potential applicants. Two pathways of research training are offered to produce Basic Laboratory Scientists or Clinical- Translational Scientists, leveraging the resources at the UCD in basic, translational, clinical and outcomes-based research. Research training will be focused in four general scientific themes: mechanisms of tissue injury and repair, immunobiology and host defense, pediatric obesity and metabolic syndrome, and health outcomes research. The T32 faculty has grown to 31 scientists with over $25 million dollars in NIH grant funding and a highly successful training record. Basic research experiences are augmented by graduate courses, seminars and multidisciplinary meetings. Trainees in clinical-translational research will participate in the Masters of Science Degree in the Clinical Sciences Graduate Program of UCD and will leverage the infrastructure of the Colorado Clinical and Translational Sciences Institute. The research training is designed to be a 2-3 year program, generally beginning in the 2nd year of subspecialty fellowship or following completion of a PhD or equivalent. Eligible candidates are primarily drawn from the nationally recognized fellowship in Pediatric Gastroenterology, with the potential for candidates in other disciplines including neonatology, nutrition and related basic science fields. Fellows are provided a minimum of 80% protected time for 2 or 3 years of training in a mentored and structured environment. The quality of the educational and research experiences will be closely monitored by the trainees, mentors and Executive Committee with defined metrics and ongoing improvement processes. Of the 16 trainees who will have completed the T32 training by 2014, 13 (81%) will have full-time academic positions and are developing their research careers. The continuation of 5 training positions is requested.

Public Health Relevance

This T32 Training Program is directly relevant to child health by training the next generation of physician and PhD scientists who will be essential to advance the care and improve the quality of life of children and adolescents with GI, hepatology and nutritional disorders. The investment in multidisciplinary bench to bedside research training in this Training Program will provide a foundation for the trainees to become the future leaders, teachers and mentors who will help guide the direction of GI, hepatology and nutrition in the future.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK067009-11
Application #
8854766
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Densmore, Christine L
Project Start
2004-01-01
Project End
2020-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
11
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Ng, Vicky L; Sorensen, Lisa G; Alonso, Estella M et al. (2018) Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study. J Pediatr 196:139-147.e3
Wright, Benjamin L; Nguyen, Nathalie; Shim, Kelly P et al. (2018) Increased GATA-3 and T-bet expression in eosinophilic esophagitis versus gastroesophageal reflux disease. J Allergy Clin Immunol 141:1919-1921.e5
Nguyen, Nathalie; Baumgarten, Anna; Wright, Benjamin L et al. (2018) Histologic similarities in children with eosinophilic esophagitis and PPI-responsive esophageal eosinophilia. J Allergy Clin Immunol :
Bednarek, Joseph; Traxinger, Brianna; Brigham, Dania et al. (2018) Cytokine-Producing B Cells Promote Immune-Mediated Bile Duct Injury in Murine Biliary Atresia. Hepatology 68:1890-1904
Nguyen, Nathalie; Kramer, Robert E; Friedlander, Joel A (2018) Videocapsule Endoscopy Identifies Small Bowel Lesions in Patients With Eosinophilic Enteritis. Clin Gastroenterol Hepatol 16:e64-e65
Nguyen, N; Fernando, S D; Biette, K A et al. (2018) TGF-?1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitis. Mucosal Immunol 11:415-426
Hoffenberg, Edward J; Newman, Heike; Collins, Colm et al. (2017) Cannabis and Pediatric Inflammatory Bowel Disease: Change Blossoms a Mile High. J Pediatr Gastroenterol Nutr 64:265-271
Whelan, Kelly A; Merves, Jamie F; Giroux, Veronique et al. (2017) Autophagy mediates epithelial cytoprotection in eosinophilic oesophagitis. Gut 66:1197-1207
Sheiko, Melissa A; Sundaram, Shikha S; Capocelli, Kelley E et al. (2017) Outcomes in Pediatric Autoimmune Hepatitis and Significance of Azathioprine Metabolites. J Pediatr Gastroenterol Nutr 65:80-85
Noel, Gillian; Diamond, Bethany; Auerbach, Scott et al. (2017) Colonic Crohn Disease After Cardiac Transplantation: Case Report and Literature Review. J Pediatr Gastroenterol Nutr 65:e45-e46

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