This application is for a renewal of training grant: """"""""Environmental and Molecular Epidemiology"""""""" that originally was established in 1990. There remains a nation-wide need for trained epidemiologists to address the increasingly complex challenges of elucidating the etiologies of environmentally-related diseases. Especially noteworthy challenges include determination of health hazards associated with low-level toxicant exposures and characterization of gene/environment interactions to identify, susceptible subgroups in the population. The goal of the training grant is to provide training to pre- and postdoctoral epidemiologists in the methods and substantive knowledge characteristic of environmental epidemiology and the related environmental sciences of toxicology, molecular genetics, and environmental exposure assessment. The ultimate objective of the training program is to prepare health professionals to function effectively in research and teaching careers. The Environmental and Molecular Epidemiology Training Grant is comprised of two tracks: 1) a general environmental epidemiology track and 2) a molecular epidemiology track. The investigators are seeking support for 4 pre- and 1 postdoctoral trainees on the general environmental epidemiology track, and for 3 pre- and 1 postdoctoral trainees on the molecular epidemiology track. A new feature will be a postdoctoral traineeship on the general track that will support a fellow in the Occupational and Environmental Medicine Program in the Department of Environmental Health. Pre-doctoral trainees will pursue doctorate (Ph.D.) degree, in epidemiology; the period of support will range from 2-5 years. Postdoctoral trainees will be eligible, but not required to seek, MS or MPH degrees in epidemiology or environmental health, toxicology option. The exception will be the occupational and environmental medicine fellow who will be required to complete the MPH degree in environmental health. Postdoctoral support will be for 2-3 years. The common feature of the training for all trainees will be a focus on environmental determinants of disease, with programs of course work and research experience tailored to fit trainees' backgrounds and specific interests. The molecular epidemiology track will emphasize the application of molecular and biochemical toxicology methods to epidemiologic research. The postdoctoral molecular epidemiology trainee will be required to have a prior doctorate in toxicology, biochemistry, molecular biology, or a related discipline. In addition to resources available in the Departments of Epidemiology and Environmental Health, significant research opportunities are provided by the NIEHS-funded Center for Ecogenetics and Environmental Health, the Fred Hutchinson Cancer Research Center, the NIEHS-funded Center for Child Environmental Health, the UW Superfund Basic Research Program Project, the UW/EPA Northwest Center for Particulate Matter Air Pollution Research, and the NIOSH-sponsored Agricultural safety and Health Center. Numerous training grant faculty either direct or are directly affiliated with one or more of these research centers. During the first 10 years of support, trainees have been successful in obtaining, appropriate classroom and research experience, including securing extramural research funding. This training grant will continue to enhance trainees' credentials necessary for productive research and teaching careers in environmental epidemiology.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Public Health & Prev Medicine
Schools of Public Health
United States
Zip Code
Jusko, Todd A; De Roos, Anneclaire J; Lee, Sue Y et al. (2016) A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination. Environ Health Perspect 124:813-21
Biggs, Mary L; Doody, David R; Trabert, Britton et al. (2016) Consumption of alcoholic beverages in adolescence and adulthood and risk of testicular germ cell tumor. Int J Cancer 139:2405-14
Barrington-Trimis, Jessica L; Cockburn, Myles; Metayer, Catherine et al. (2015) Rising rates of acute lymphoblastic leukemia in Hispanic children: trends in incidence from 1992 to 2011. Blood 125:3033-4
Krenz, Jennifer E; Hofmann, Jonathan N; Smith, Theresa R et al. (2015) Determinants of butyrylcholinesterase inhibition among agricultural pesticide handlers in Washington State: an update. Ann Occup Hyg 59:25-40
Sathyanarayana, Sheela; Barrett, Emily; Butts, Samantha et al. (2014) Phthalate exposure and reproductive hormone concentrations in pregnancy. Reproduction 147:401-9
Strelitz, Jean; Engel, Lawrence S; Keifer, Matthew C (2014) Blood acetylcholinesterase and butyrylcholinesterase as biomarkers of cholinesterase depression among pesticide handlers. Occup Environ Med 71:842-7
Barrington-Trimis, Jessica L; Searles Nielsen, Susan; Preston-Martin, Susan et al. (2013) Parental smoking and risk of childhood brain tumors by functional polymorphisms in polycyclic aromatic hydrocarbon metabolism genes. PLoS One 8:e79110
Williams, Lori; Ulrich, Cornelia M; Larson, Timothy et al. (2011) Fine particulate matter (PM?.?) air pollution and immune status among women in the Seattle area. Arch Environ Occup Health 66:155-65
Jusko, Todd A; De Roos, Anneclaire J; Schwartz, Stephen M et al. (2011) Maternal and early postnatal polychlorinated biphenyl exposure in relation to total serum immunoglobulin concentrations in 6-month-old infants. J Immunotoxicol 8:95-100
Checkoway, H; Ray, R M; Lundin, J I et al. (2011) Lung cancer and occupational exposures other than cotton dust and endotoxin among women textile workers in Shanghai, China. Occup Environ Med 68:425-9

Showing the most recent 10 out of 71 publications