It clearly emerges from """"""""Vision Research;A National Plan"""""""" that vision research embraces every discipline in the biological sciences as well as cognitive sciences and clinical research. Participation by the NEI in the NIH Roadmap reflects recognition by vision scientists of the importance of the interdisciplinary approach to research, and of rapid translation of findings in basic research to clinical care. Accordingly, the next generation of vision scientists will need to develop their scientific skills within an environment that stresses cutting edge science, interdisciplinary cooperation, an understanding of the visual system, and exposure to clinical ophthalmology. This training program, while broad in the scope of participating scientific disciplines, is focused on creating at the University of Pittsburgh a training environment that will favor interactions and collaborations among vision scientists, and involve predoctoral students and postdoctoral fellows in interdisciplinary approaches to understanding the visual system and ocular diseases. Although this T32 application focuses on training of basic scientists, our trainees will have frequent interactions with clinical ophthalmologists who will serve as mentors, lecturers in our didactic vision course, and pending successful development of our ophthalmology K12 program, close interactions between basic scientist trainees in our T32 grant and the physician-scientists being trained within the K12 program through shared course work, seminars, and data clubs. Our T32 training program will draw graduate students from the Immunology, Molecular Virology and Microbiology, Neuroscience, Cell Biology and Molecular Physiology, Human Genetics, and Bioengineering graduate training programs. These programs will provide the structure and basic curriculum, whereas the T32 training program will provide specialized training in vision research. The proposed program will also provide a structure for training of postdoctoral fellows in vision research that will coordinate with the significant support structure already in place at the university. We will strive to attract the brightest students and postdocs with the goals of providing 1) a basic understanding of the anatomy, physiology, and diseases of the eye;2) appreciation and utilization of the unique anatomical and physiological characteristics of the eye;and 3) awareness of the strengths and limitations of available animal models for ocular diseases.

National Institute of Health (NIH)
National Eye Institute (NEI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Agarwal, Neeraj
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pittsburgh
Schools of Medicine
United States
Zip Code
Jan, Ning-Jiun; Brazile, Bryn L; Hu, Danielle et al. (2018) Crimp around the globe; patterns of collagen crimp across the corneoscleral shell. Exp Eye Res 172:159-170
Tran, Huong; Wallace, Jacob; Zhu, Ziyi et al. (2018) Seeing the Hidden Lamina: Effects of Exsanguination on the Optic Nerve Head. Invest Ophthalmol Vis Sci 59:2564-2575
Murphy, Matthew C; Chan, Kevin C; Kim, Seong-Gi et al. (2018) Macroscale variation in resting-state neuronal activity and connectivity assessed by simultaneous calcium imaging, hemodynamic imaging and electrophysiology. Neuroimage 169:352-362
Brazile, Bryn L; Hua, Yi; Jan, Ning-Jiun et al. (2018) Thin Lamina Cribrosa Beams Have Different Collagen Microstructure Than Thick Beams. Invest Ophthalmol Vis Sci 59:4653-4661
Hua, Yi; Voorhees, Andrew P; Sigal, Ian A (2018) Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics. Invest Ophthalmol Vis Sci 59:154-165
Voorhees, Andrew P; Jan, Ning-Jiun; Hua, Yi et al. (2018) Peripapillary sclera architecture revisited: A tangential fiber model and its biomechanical implications. Acta Biomater 79:113-122
Wang, Bo; Lucy, Katie A; Schuman, Joel S et al. (2018) Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa. Sci Rep 8:7281
Stella, Nicholas A; Brothers, Kimberly M; Callaghan, Jake D et al. (2018) An IgaA/UmoB Family Protein from Serratia marcescens Regulates Motility, Capsular Polysaccharide Biosynthesis, and Secondary Metabolite Production. Appl Environ Microbiol 84:
Yang, Bin; Jan, Ning-Jiun; Brazile, Bryn et al. (2018) Polarized light microscopy for 3-dimensional mapping of collagen fiber architecture in ocular tissues. J Biophotonics 11:e201700356
Voorhees, Andrew P; Jan, Ning-Jiun; Austin, Morgan E et al. (2017) Lamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult. Invest Ophthalmol Vis Sci 58:5336-5346

Showing the most recent 10 out of 46 publications