This application seeks support to continue a successful and long-standing predoctoral training program in Cellular and Molecular Biology. The proposed program will provide multidisciplinary training for 16 predoctoral students. The training program has evolved over the past 30 years to provide a curriculum that offers both breadth and depth in the area of cellular and molecular biology. Graduate training at Cornell University is administered by Graduate Fields that provide the flexibility of having faculty participation from multiple departments. The Graduate Field of Biochemistry, Molecular and Cell Biology, which administers this training grant, includes 46 faculty members who represent eleven undergraduate Departments. Thus, a major asset of this program is the large core of highly qualified faculty in diverse areas. These faculty members bring not only unique perspectives to training students in cellular to molecular biology but also provide the multidisciplinary perspective that contributes so effectively to solving biological problems. Students admitted to the Program will have undergraduate degrees in the biological or physical sciences. A comprehensive set of lecture and laboratory courses and laboratory rotations make up the first year, of the Program, followed by research, additional courses, and an obligatory teaching requirement during the second year. In addition to their major subject, trainees select a minor graduate subject in which they broaden their training by taking selected courses. The remaining time is devoted mainly to research, as well as to continue training through attending and presenting seminars and by association with faculty and postdoctoral fellows across the breadth of this training environment. Monitoring of the progress of students continues through the complete tenure of our students. The entire Field meets to assess the first year lab rotations and course performance, and a student's special committee meets yearly to assess progress following the student's yearly research seminar. Excellent facilities are available to the program at Cornell, providing modern research laboratories and state-of-the-art core services that include DMA sequencing, microarrays, peptide sequencing, flow cytometry, confocal microscopy, X-ray diffraction, and mass spectrometry.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM007273-31
Application #
6894422
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Zatz, Marion M
Project Start
1975-07-01
Project End
2010-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
31
Fiscal Year
2005
Total Cost
$617,052
Indirect Cost
Name
Cornell University
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
872612445
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Beacham, Gwendolyn M; Partlow, Edward A; Lange, Jeffrey J et al. (2018) NECAPs are negative regulators of the AP2 clathrin adaptor complex. Elife 7:
Thomas, Laura L; Joiner, Aaron M N; Fromme, J Christopher (2018) The TRAPPIII complex activates the GTPase Ypt1 (Rab1) in the secretory pathway. J Cell Biol 217:283-298
Halaby, Steve L; Fromme, J Christopher (2018) The HUS box is required for allosteric regulation of the Sec7 Arf-GEF. J Biol Chem 293:6682-6691
Siegenthaler, Kevin D; Pareja, Kristeen A; Wang, Jie et al. (2017) An unexpected role for the yeast nucleotide exchange factor Sil1 as a reductant acting on the molecular chaperone BiP. Elife 6:
Liberti, Maria V; Dai, Ziwei; Wardell, Suzanne E et al. (2017) A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab 26:648-659.e8
Wang, Alex B; Zhang, Ying V; Tumbar, Tudorita (2017) Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation. EMBO J 36:61-78
Pierpont, Timothy M; Lyndaker, Amy M; Anderson, Claire M et al. (2017) Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer. Cell Rep 21:1896-1909
Gustafson, Margaret A; Fromme, J Christopher (2017) Regulation of Arf activation occurs via distinct mechanisms at early and late Golgi compartments. Mol Biol Cell 28:3660-3671
Liu, Yi; Cussiol, José Renato; Dibitetto, Diego et al. (2017) TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9. J Cell Biol 216:623-639
Taylor, David H; McLean, Chelsea M; Wu, Warren L et al. (2016) Imprinted DNA methylation reconstituted at a non-imprinted locus. Epigenetics Chromatin 9:41

Showing the most recent 10 out of 124 publications