Continued support is requested for graduate training in Molecular and Cell Biology and Biochemistry for a talented cohort of predoctoral students in the Graduate Program in Molecular Biology, Cell Biology and Biochemistry (MCB) at Brown University. The MCB Graduate Program is an interdepartmental interdisciplinary program, which admits 8-12 students per year based on both their research and academic achievements. During the second or third year of graduate study, trainees will be selected from the ~20 eligible MCB graduate students for appointment to the training grant on the basis of their potential for success in research. Each year, 4 or 5 trainees will be appointed for a period of two years; funds to support 9 trainees per year are requested. Faculty trainers in the MCB Graduate Program are accomplished scientists who are drawn from 12 Departments at Brown University and the Warren Alpert Medical School, as well as from the Marine Biology Laboratory at Woods Hole. The mission of the MCB Graduate Program is to train the next generation of scientists to probe the molecular mechanisms of cellular and developmental processes. While the ultimate goal of advanced study in experimental biology is specialization, the MCB Graduate Program balances this focus with broad multidisciplinary training, equipping our students to pursue issues central to basic biology and human health without approach-imposed limitations. This comprehensive perspective sets the multidepartmental MCB Graduate Program apart from the eight other discipline-specific training programs at Brown, providing a unique opportunity for students to erase the boundaries between fields.

Public Health Relevance

Solving the complex problems in human health and modern biology will require the development of interdisciplinary approaches by the next generation of experimental biologists. Accordingly, this program is designed to provide students with broad and deep knowledge in diverse but interrelated experimental fields and to offer training at the interfaces of scientific disciplines.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
3T32GM007601-37S1
Application #
9248471
Study Section
Training and Workforce Development Subcommittee - D (TWD)
Program Officer
Gindhart, Joseph G
Project Start
1979-09-01
Project End
2020-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
37
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Brown University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
Monaghan, Sean F; Banerjee, Debasree; Chung, Chun-Shiang et al. (2018) Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness. Mol Med 24:32
Ryan, Veronica H; Dignon, Gregory L; Zerze, G├╝l H et al. (2018) Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation. Mol Cell 69:465-479.e7
Beekman, Chapman N; Meckler, Lauren; Kim, Eleanor et al. (2018) Galleria mellonella as an insect model for P. destructans, the cause of White-nose Syndrome in bats. PLoS One 13:e0201915
Fresques, Tara M; Wessel, Gary M (2018) Nodal induces sequential restriction of germ cell factors during primordial germ cell specification. Development 145:
Jeschonek, Samantha P; Mowry, Kimberly L (2018) Whole-Mount Immunofluorescence for Visualizing Endogenous Protein and Injected RNA in Xenopus Oocytes. Cold Spring Harb Protoc 2018:pdb.prot097022
Perry, Jenna A; Sinclair-Davis, Amy N; McAllaster, Michael R et al. (2018) TbSmee1 regulates hook complex morphology and the rate of flagellar pocket uptake in Trypanosoma brucei. Mol Microbiol 107:344-362
Fratta, Pietro; Sivakumar, Prasanth; Humphrey, Jack et al. (2018) Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. EMBO J 37:
Neil, Christopher R; Mowry, Kimberly (2018) Fluorescence In Situ Hybridization of Cryosectioned Xenopus Oocytes. Cold Spring Harb Protoc 2018:pdb.prot097030
Fedry, Juliette; Forcina, Jennifer; Legrand, Pierre et al. (2018) Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes. PLoS Biol 16:e2006357
Janke, Abigail M; Seo, Da Hee; Rahmanian, Vahid et al. (2018) Lysines in the RNA Polymerase II C-Terminal Domain Contribute to TAF15 Fibril Recruitment. Biochemistry 57:2549-2563

Showing the most recent 10 out of 203 publications