The Integrated Program in Cellular, Molecular and Biophysical Studies at Columbia University College of Physicians and Surgeons is a Ph.D. granting program that combines faculty from all seven basic science departments at the Medical Center. The program started out as the interdisciplinary nature of biomedical research became more obvious and the need for interdepartmental """"""""core courses"""""""" was perceived specifically to educate graduate students in the basics of biochemistry, molecular biology, genetics and cell biology. The Integrated Program was formally established as a degree-granting program in 1986 and the program was funded by NIGMS in 1987. The program has a distinguished, well-funded faculty of 98 trainers, whose research expertise represents nearly all the areas of modern cellular and molecular biology and molecular biophysics. There are currently 67 students in the Program. Students take four core courses and a course in the Responsible Conduct of Research in the first year and complete three laboratory rotations. At the end of the first year, they choose their thesis mentor and take a qualifying examination. In subsequent years, the students take three elective courses and complete their thesis research. The Program sponsors a """"""""Frontiers in Cell Biology"""""""" seminar series, a student research seminar series and a biennial student-faculty retreat. Most students complete the Program in 5-6 years. Fifty students have graduated from the Program in the past five years alone and nearly all have gone on to post-doctoral positions in outstanding laboratories. Based on the continued growth in the pool of training grant eligible applicants to this Program and the size and strength of the Training Faculty, we request support for 15 students each year.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Zatz, Marion M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Columbia University (N.Y.)
Schools of Medicine
New York
United States
Zip Code
Van Alstyne, Meaghan; Simon, Christian M; Sardi, S Pablo et al. (2018) Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy. Genes Dev 32:1045-1059
Zhang, Liyang; Martini, Gabriella D; Rube, H Tomas et al. (2018) SelexGLM differentiates androgen and glucocorticoid receptor DNA-binding preference over an extended binding site. Genome Res 28:111-121
Singh, Appu K; McGoldrick, Luke L; Twomey, Edward C et al. (2018) Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6. Sci Adv 4:eaau6088
Singer, Ruth A; Sussel, Lori (2018) Islet Long Noncoding RNAs: A Playbook for Discovery and Characterization. Diabetes 67:1461-1470
Weyn-Vanhentenryck, Sebastien M; Feng, Huijuan; Ustianenko, Dmytro et al. (2018) Precise temporal regulation of alternative splicing during neural development. Nat Commun 9:2189
Jacko, Martin; Weyn-Vanhentenryck, Sebastien M; Smerdon, John W et al. (2018) Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly. Neuron 97:853-868.e6
Yuan, Jinzhou; Levitin, Hanna Mendes; Frattini, Veronique et al. (2018) Single-cell transcriptome analysis of lineage diversity in high-grade glioma. Genome Med 10:57
Tzoneva, Gannie; Dieck, Chelsea L; Oshima, Koichi et al. (2018) Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia. Nature 553:511-514
Rastogi, Chaitanya; Rube, H Tomas; Kribelbauer, Judith F et al. (2018) Accurate and sensitive quantification of protein-DNA binding affinity. Proc Natl Acad Sci U S A 115:E3692-E3701
Twomey, Edward C; Sobolevsky, Alexander I (2018) Structural Mechanisms of Gating in Ionotropic Glutamate Receptors. Biochemistry 57:267-276

Showing the most recent 10 out of 88 publications