Molecular biophysics at the University of Pennsylvania has a long and rich history. Eldridge Reeves Johnson, the former president of the Victor Talking Machine Company (RCA), gave the University a generous endowment in 1927 to establish a foundation in medical physics. The Johnson Foundation (JF) was dedicated to the """"""""study and development of physical methods in the investigation of disease and in its cure"""""""". The JF was the first organization in this country dedicated to biophysics. Under the leadership of Detlev Bronk, investigators developed and expanded methods for recording action potentials in nerves, developed innovative techniques of oxygen electrode measurements, and explored new technologies such as ultrasound and electron microscopy. Under the leadership of Britton Chances optical methods were pioneered at Penn to study cell organelles and tissues. In addition, research in the JF mapped out much of the molecular machinery of respiration and energy metabolism. The JF was also instrumental in pioneering the use of nuclear magnetic resonance spectroscopy to visualize biochemical processes in intact tissues. The Johnson Foundation, now under the direction of P. Leslie Dutton, has continued to evolve and expand into structural and computational biology, high resolution NMR spectroscopy, and protein folding. True to the mandate of the Johnson Foundation, biophysical methodologies are being used to explore fundamental processes that are vital to human biology and disease.

Public Health Relevance

The training program in Structural Biology and Molecular Biophysics at the University of Pennsylvania promotes the application of biophysics to clinically relevant research. The fundamental goal of our training mission is to produce biophysicists who can effectively integrate and apply the physical methodologies to medically relevant research problems. Our program explicitly integrates human biology and pathology into the graduate curriculum. The SBMB training program is designed to produce well-rounded scientists with expertise in structural biology and biophysics as well as have a solid foundation biomedical sciences and disease.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-BRT-X (TG))
Program Officer
Flicker, Paula F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
Schools of Medicine
United States
Zip Code
O'Brien, Evan S; Lin, Danny W; Fuglestad, Brian et al. (2018) Improving yields of deuterated, methyl labeled protein by growing in H2O. J Biomol NMR 71:263-273
Vara, Brandon A; Li, Xingpin; Berritt, Simon et al. (2018) Scalable thioarylation of unprotected peptides and biomolecules under Ni/photoredox catalysis. Chem Sci 9:336-344
Caro, José A; Wand, A Joshua (2018) Practical aspects of high-pressure NMR spectroscopy and its applications in protein biophysics and structural biology. Methods 148:67-80
Bagchi, Atrish; Haidar, Jaafar N; Eastman, Scott W et al. (2018) Molecular Basis for Necitumumab Inhibition of EGFR Variants Associated with Acquired Cetuximab Resistance. Mol Cancer Ther 17:521-531
Yuan, Zuo-Fei; Sidoli, Simone; Marchione, Dylan M et al. (2018) EpiProfile 2.0: A Computational Platform for Processing Epi-Proteomics Mass Spectrometry Data. J Proteome Res 17:2533-2541
Guo, Lin; Kim, Hong Joo; Wang, Hejia et al. (2018) Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell 173:677-692.e20
Walters, Christopher R; Ferrie, John J; Petersson, E James (2018) Dithioamide substitutions in proteins: effects on thermostability, peptide binding, and fluorescence quenching in calmodulin. Chem Commun (Camb) 54:1766-1769
Sutherland, George A; Grayson, Katie J; Adams, Nathan B P et al. (2018) Probing the quality control mechanism of the Escherichia coli twin-arginine translocase with folding variants of a de novo-designed heme protein. J Biol Chem 293:6672-6681
Armour, Sean M; Remsberg, Jarrett R; Damle, Manashree et al. (2017) An HDAC3-PROX1 corepressor module acts on HNF4? to control hepatic triglycerides. Nat Commun 8:549
Das, Arunika; Smoak, Evan M; Linares-Saldana, Ricardo et al. (2017) Centromere inheritance through the germline. Chromosoma 126:595-604

Showing the most recent 10 out of 209 publications