The Molecular Biophysics Training Grant at Harvard supports a predoctoral training program focused at the interface of the physical and biological sciences. The goal of the program is to provide students with strong undergraduate backgrounds in quantitative sciences (especially physics and mathematics) with broad training in the biophysical, chemical and molecular concepts and techniques that are required to address outstanding problems in biology and biomedical sciences. The training program links a highly interactive group of 46 faculty members from five departments in Harvard's Faculty of Arts and Sciences, the School of Engineering and Applied Sciences, five departments at Harvard Medical School, and four affiliated hospitals. The training program offers a flexible curriculum drawn from courses offered at Harvard, Harvard Medical School, and MIT, and offers research opportunities in a variety of disciplines relevant to molecular biophysics with particular strengths in the areas of structural biology, computational biology, neuroscience, and imaging. In addition to coursework and research activities, the training program sponsors seminars and guest lectures;a student run, student research seminar series;a yearly retreat featuring a poster session and student and faculty talks in the fall semester;a poster session featuring research of program students;a mini- symposium featuring talks by program faculty during the Biophysics Program recruiting weekend in the spring semester;and social events for all trainees. Over the past 24 years, this training program has helped foster a number of new initiatives in graduate training, and has been remarkably successful in promoting collaborative research among its faculty and interdisciplinary training for its students. In this competitive renewal we request support for 16 training slots for students who are affiliated with Harvard's Biophysics Program or who are jointly affiliated with the Harvard Biophysics Program and Medical Engineering and Medical Physics (MEMP) Ph.D. program in the joint Harvard/MIT Health Sciences and Technology initiative (HST). Students will be preferentially funded in their first and second year of graduate studies.

Public Health Relevance

This training program offers interdisciplinary training at the interface between biology and physics in approaches to explore the structure, function and interactions key macromolecules of the cell, the control of cellular processes at the molecular and genome-wide levels, the development of approaches to imaging and modeling these processes, and ultimately the use of this information to diagnose, understand, prevent or cure human diseases.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Program Officer
Flicker, Paula F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Harvard Medical School
Schools of Medicine
United States
Zip Code
Stolte, Björn; Iniguez, Amanda Balboni; Dharia, Neekesh V et al. (2018) Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. J Exp Med 215:2137-2155
Wang, Songyu; Powers, Robert E; Gold, Vicki Am et al. (2018) The ER morphology-regulating lunapark protein induces the formation of stacked bilayer discs. Life Sci Alliance 1:e201700014
Lin, Jia-Ren; Izar, Benjamin; Wang, Shu et al. (2018) Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes. Elife 7:
Kimchi, Ofer; Veatch, Sarah L; Machta, Benjamin B (2018) Ion channels can be allosterically regulated by membrane domains near a de-mixing critical point. J Gen Physiol 150:1769-1777
Jenkins, Russell W; Aref, Amir R; Lizotte, Patrick H et al. (2018) Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov 8:196-215
Harris, Nicholas C; Born, David A; Cai, Wenlong et al. (2018) Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase. Angew Chem Int Ed Engl 57:9707-9710
Born, David A; Ulrich, Emily C; Ju, Kou-San et al. (2017) Structural basis for methylphosphonate biosynthesis. Science 358:1336-1339
Weisman, Caroline M; Eddy, Sean R (2017) Gene Evolution: Getting Something from Nothing. Curr Biol 27:R661-R663
Steinhorn, Benjamin; Sartoretto, Juliano L; Sorrentino, Andrea et al. (2017) Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4. Free Radic Biol Med 113:16-25
Powers, Robert E; Wang, Songyu; Liu, Tina Y et al. (2017) Reconstitution of the tubular endoplasmic reticulum network with purified components. Nature 543:257-260

Showing the most recent 10 out of 91 publications