The objective of this program is to train pharmaceutical scientists to handle the development of products arising from biotechnology research. Due to the difficulty and complex nature of developing biotechnology- derived drugs, it is necessary to train a new """"""""breed"""""""" of pharmaceutical scientists who can respond to the needs of interdisciplinary approaches for the advancements of biological, chemical, and pharmaceutical sciences by integrating mathematics, physics, biology, molecular biology, and chemistry to solve difficult problems in designing therapeutic agents of the future. This new type of scientist could also be placed in academic institutions to expand the educational training of pharmaceutical biotechnology scientists of the future. This training program has been in existence for 20 years with 8 students per year and 34 faculty mentors. There are two major areas of research in this training program: (1) the traditional""""""""Pharmaceutics"""""""" area that includes formation, analysis, and delivery and (2) the protein structure and bioinformatics area. The 34 faculty mentors are from four different departments, including Chemistry, Medicinal Chemistry, Molecular Biosciences, and Pharmaceutical Chemistry. The faculty mentors are also involved in several other programs within The University of Kansas, including the Adams Institute for Bioanalytical Chemistry, the Bioengineering Program, the Bioinformatics Center, and the Center of Excellence for Protein Structure and Function. The Steering Committee oversees all aspects of the training program and Dr. Siahaan (PI) serves as the committee chair. The students will be selected from a pool of applicants that are nominated by the faculty mentors from the participating departments. The Steering Committee will select the trainees from the nominated students each year. The students'progress will be monitored in quarterly meetings and annual symposia organized by the trainees under the supervision of a member of the Steering Committee. The trainees will be supported by the training program for a maximum of two years and the past trainees who are not yet graduated are expected to participate in all activities administered by the training program. The alumni of this program who have been working for five years in industry and academia will be invited to present their research at the yearly symposium. The alumni will provide feedback on the training program and the feedback will be used to improve the quality of the training program in the future.
The objective of this program is to train pharmaceutical scientists to handle the development of products arising from biotechnology research. This training program is fulfilling the need to produce a new """"""""breed"""""""" of future scientists that can respond to the complex nature of discovering and developing therapeutic agents derived from biotechnology research. The hope is that these future scientists will improve the probability of success in developing these future therapeutic agents from the bench to the bedside.
|More, Apurva S; Toth 4th, Ronald T; Okbazghi, Solomon Z et al. (2018) Impact of Glycosylation on the Local Backbone Flexibility of Well-Defined IgG1-Fc Glycoforms Using Hydrogen Exchange-Mass Spectrometry. J Pharm Sci 107:2315-2324|
|Toth 4th, Ronald T; Pace, Samantha E; Mills, Brittney J et al. (2018) Evaluation of Hydrogen Exchange Mass Spectrometry as a Stability-Indicating Method for Formulation Excipient Screening for an IgG4 Monoclonal Antibody. J Pharm Sci 107:1009-1019|
|Mills, Brittney J; Laurence Chadwick, Jennifer S (2018) Effects of localized interactions and surface properties on stability of protein-based therapeutics. J Pharm Pharmacol 70:609-624|
|Franklin, Meghan Whitney; Nepomnyachiy, Sergey; Feehan, Ryan et al. (2018) Efflux Pumps Represent Possible Evolutionary Convergence onto the ?-Barrel Fold. Structure 26:1266-1274.e2|
|Machen, Alexandra J; O'Neil, Pierce T; Pentelute, Bradley L et al. (2018) Analyzing Dynamic Protein Complexes Assembled On and Released From Biolayer Interferometry Biosensor Using Mass Spectrometry and Electron Microscopy. J Vis Exp :|
|Franklin, Meghan Whitney; Slusky, Joanna S G (2018) Tight Turns of Outer Membrane Proteins: An Analysis of Sequence, Structure, and Hydrogen Bonding. J Mol Biol 430:3251-3265|
|Wei, Yangjie; Xiong, Jian; Larson, Nicholas R et al. (2018) Effect of 2 Emulsion-Based Adjuvants on the Structure and Thermal Stability of Staphylococcus aureus Alpha-Toxin. J Pharm Sci 107:2325-2334|
|Knewtson, Kelsey E; Rane, Digamber; Peterson, Blake R (2018) Targeting Fluorescent Sensors to Endoplasmic Reticulum Membranes Enables Detection of Peroxynitrite During Cellular Phagocytosis. ACS Chem Biol 13:2595-2602|
|Pace, Samantha E; Joshi, Sangeeta B; Esfandiary, Reza et al. (2018) The Use of a GroEL-BLI Biosensor to Rapidly Assess Preaggregate Populations for Antibody Solutions Exhibiting Different Stability Profiles. J Pharm Sci 107:559-570|
|Dennis, S Connor; Whitlow, Jonathan; Detamore, Michael S et al. (2017) Hyaluronic-Acid-Hydroxyapatite Colloidal Gels Combined with Micronized Native ECM as Potential Bone Defect Fillers. Langmuir 33:206-218|
Showing the most recent 10 out of 105 publications