The University of North Carolina (UNC) Molecular and Cellular Biophysics Program (MCBP) is a highly successful interdisciplinary graduate training program with three essential goals: 1. To attract a diverse cohort of talented post-graduate students to apply the methods and concepts of the quantitative and mathematical sciences to problems in biology; 2. To provide a flexible vehicle for training this diverse group o graduate students who share with our biophysics faculty a commitment to developing molecular level descriptions of complex biological systems and processes; 3. To foster interactions and enhance the training and research environment within this diverse group of faculty and students. Having weathered State and Federal budget cuts as well as significant reorganization of graduate training in the biomedical sciences, the MCBP remains vibrant and central to the success of interdisciplinary biophysical research at UNC-Chapel Hill. The retiring Program Director has recruited as future Co-Directors two committed and energetic young faculty from participating departments located in UNC's two principle academic centers: School of Medicine & College of Arts and Sciences. They are ideally positioned to maintain the Program's rigor, adaptability, and visibility as well as to garner resources to guarantee its future success. This application is for continued funding of this successful training program in an area critical to biomedical research.

Public Health Relevance

Biophysics is an interdisciplinary field of the biomedical sciences that aims to understand the mechanism of human health and disease on a molecular scale using the tools of the physical and quantitative sciences. The Molecular and Cellular Biophysics Program (MCBP) at the University of North Carolina at Chapel Hill is an established and highly successful training program in biophysics that seeks refunding in order to train students for this rapidly advancing and critical field.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008570-23
Application #
9320764
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Flicker, Paula F
Project Start
1995-07-01
Project End
2018-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
23
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Biochemistry
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Adikes, Rebecca C; Hallett, Ryan A; Saway, Brian F et al. (2018) Control of microtubule dynamics using an optogenetic microtubule plus end-F-actin cross-linker. J Cell Biol 217:779-793
Haase, Karen P; Fox, Jaime C; Byrnes, Amy E et al. (2018) Stu2 uses a 15-nm parallel coiled coil for kinetochore localization and concomitant regulation of the mitotic spindle. Mol Biol Cell 29:285-294
Kirkpatrick, Christine L; Parsley, Nicole C; Bartges, Tessa E et al. (2018) Fungal Secretome Analysis via PepSAVI-MS: Identification of the Bioactive Peptide KP4 from Ustilago maydis. J Am Soc Mass Spectrom 29:859-865
Jiang, Yuhang; Fay, James M; Poon, Chi-Duen et al. (2018) Nanoformulation of Brain-Derived Neurotrophic Factor with Target Receptor-Triggered-Release in the Central Nervous System. Adv Funct Mater 28:
Guseman, Alex J; Speer, Shannon L; Perez Goncalves, Gerardo M et al. (2018) Surface Charge Modulates Protein-Protein Interactions in Physiologically Relevant Environments. Biochemistry 57:1681-1684
Stadmiller, Samantha S; Pielak, Gary J (2018) Enthalpic stabilization of an SH3 domain by D2 O. Protein Sci 27:1710-1716
Kirk, Jessime M; Kim, Susan O; Inoue, Kaoru et al. (2018) Functional classification of long non-coding RNAs by k-mer content. Nat Genet 50:1474-1482
Kirkpatrick, Christine L; Parsley, Nicole C; Bartges, Tessa E et al. (2018) Exploring bioactive peptides from bacterial secretomes using PepSAVI-MS: identification and characterization of Bac-21 from Enterococcus faecalis pPD1. Microb Biotechnol 11:943-951
Little, Michael S; Pellock, Samuel J; Walton, William G et al. (2018) Structural basis for the regulation of ?-glucuronidase expression by human gut Enterobacteriaceae. Proc Natl Acad Sci U S A 115:E152-E161
Patteson, Jon B; Cai, Wenlong; Johnson, Rachel A et al. (2018) Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin. Biochemistry 57:61-65

Showing the most recent 10 out of 96 publications