This application requests continued support of the Medical Scientist Training Program at the Medical University of South Carolina. The major goal is to train the next generation of physician-scientists who will choose a career that will conduct research that integrates both the basic and clinical sciences to improve human health and treat diseases. The program was originally founded in 1980 and has steadily grown to its current size of 56 students, with 32% females and 11% underrepresented minorities. Of these 136 alumni, 6 are Professors, 3 holding endowed chairs, 10 associate professors, 21 assistant professors, 6 conduct research in industry, 1 is at the NIH, 2 are at the VA, 8 are clinical faculty (instructor-assistant professor), 27 in private practice, 52 still in training, 1 unknown and 2 deceased. Our 2018 applicant pool is the largest ever with 208 applications. Over the past 5 years (2013-2018) the average number of applicants has been 189/yr, compared to the previous 5-yr average of 152/yr, which is a 24% increase. This increase in our trainee candidate pool reflects a combination of MUSC?s exceptional research environment, our MSTP students? outstanding accomplishments, and the program?s national recruitment efforts, which includes personal contacts and a recruitment letter with brochure sent to students who took the MCAT and received a score of >514 or better. The growth in the quality and quantity of our applicants provides the basis for the requested 10 positions per year. Our program in the medical school is changing to an integrated flex curriculum. In this curriculum, the first two years will be condensed into 18 months, with frequent short vacations. The new preclerkship (FLEX) curriculum will increase flexibility for graduate students to re-enter into medical school. In addition to rigorous basic science research training and medical school, trainees gain experiences in translational research via the Translational Sciences Clinic, a month in the Research Nexus and the Translational Medicine Seminar series. The objectives for the next phase are to: 1) continue the rigorous research training in areas of biomedical research by collaborative and highly accomplished faculty with exceptional records of training and research, 2) offer a training program that challenges students to think independently and critically, 3) conduct the training in a challenging, interactive environment that embraces basic, clinical and translational sciences, 4) utilize individualized development plans to enhance the training experience, 5) continue the rigorous and formal evaluation of the program that uses both quantitative and qualitative data to ensure the most rigorous, effective and efficient training, and 6) institute entrepreneurship training.

Public Health Relevance

This training program supports students pursuing the dual MD/PhD degree who will receive rigorous and directed training in the basic and clinical sciences and exposure to translation research. They are expected to be future academic physician-scientists able to conduct both basic and clinical/translational research. They will be capable of bridging the basic and clinical sciences in order to perform research at the cutting edge and become leaders in their respective fields.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Maas, Stefan
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
Schools of Medicine
United States
Zip Code
McKinnon, Emilie T; Helpern, Joseph A; Jensen, Jens H (2018) Modeling white matter microstructure with fiber ball imaging. Neuroimage 176:11-21
Herr, Daniel J; Baarine, Mauhamad; Aune, Sverre E et al. (2018) HDAC1 localizes to the mitochondria of cardiac myocytes and contributes to early cardiac reperfusion injury. J Mol Cell Cardiol 114:309-319
Berthiaume, Andrée-Anne; Grant, Roger I; McDowell, Konnor P et al. (2018) Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain. Cell Rep 22:8-16
Hartmann, David A; Hyacinth, Hyacinth I; Liao, Francesca-Fang et al. (2018) Does pathology of small venules contribute to cerebral microinfarcts and dementia? J Neurochem 144:517-526
Knochelmann, Hannah M; Dwyer, Connor J; Bailey, Stefanie R et al. (2018) When worlds collide: Th17 and Treg cells in cancer and autoimmunity. Cell Mol Immunol 15:458-469
McKinnon, Emilie T; Jensen, Jens H (2018) Measuring intra-axonal T2 in white matter with direction-averaged diffusion MRI. Magn Reson Med :
Roberts-Wolfe, Douglas; Bobadilla, Ana-Clara; Heinsbroek, Jasper A et al. (2018) Drug Refraining and Seeking Potentiate Synapses on Distinct Populations of Accumbens Medium Spiny Neurons. J Neurosci 38:7100-7107
Shih, Andy Y; Hyacinth, Hyacinth I; Hartmann, David A et al. (2018) Rodent Models of Cerebral Microinfarct and Microhemorrhage. Stroke 49:803-810
Mohanty, Vaibhav; McKinnon, Emilie T; Helpern, Joseph A et al. (2018) Comparison of cumulant expansion and q-space imaging estimates for diffusional kurtosis in brain. Magn Reson Imaging 48:80-88
Knochelmann, Hannah M; Smith, Aubrey S; Dwyer, Connor J et al. (2018) CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies. Front Immunol 9:1740

Showing the most recent 10 out of 119 publications