This program entitled """"""""The Cellular and Molecular Foundations of Biomedical Science"""""""" provides graduate training toward the Ph.D. in Biological Sciences and emphasizes a broad fundamental approach to understanding problems in modem biology. Fundamental to the course is the requirement that students take a two-semester Core Course, covering genetics, molecular biology, cell biology, neurobiology, and developmental biology. In general the program builds upon this course and other requirements in the Department of Biological Sciences, but takes advantage of an enlarged group of faculty advisors. Most of the additional faculty comes from the Columbia College for Physicians and Surgeons. This enlarged faculty provides extensive research opportunities, utilizing a variety of organisms and systems, in cell biology, developmental biology, genetics, molecular biology, structural biology, immunology, and neurobiology. Students in the program take courses tailored to their needs, participate in journal clubs and special interest group meetings, are able to do rotations, and eventually thesis research, with any of the participating faculty. Fifteen 5 graduate traineeships are requested (to support five students in the second, third, and fourth years) for a total estimated student pool of 59 working with any of 50 mentors. The choice of trainees is based on their undergraduate records, their performance in the Core Course, and the recommendation of the rotation sponsors. In general, traineeships go to the very best students, but among these, preference will be given to students involved in collaborative projects involving faculty in different departments. The facilities for research in the Department of Biological Sciences and in the Medical School Departments are outstanding.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008798-08
Application #
7455310
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Zatz, Marion M
Project Start
2001-07-01
Project End
2009-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
8
Fiscal Year
2008
Total Cost
$304,782
Indirect Cost
Name
Columbia University (N.Y.)
Department
Biology
Type
Other Domestic Higher Education
DUNS #
049179401
City
New York
State
NY
Country
United States
Zip Code
10027
Smith, Michael J; Bryant, Eric E; Rothstein, Rodney (2018) Increased chromosomal mobility after DNA damage is controlled by interactions between the recombination machinery and the checkpoint. Genes Dev 32:1242-1251
Conlon, Erin G; Fagegaltier, Delphine; Agius, Phaedra et al. (2018) Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism. Elife 7:
Lin, Yu-Cheng; Cornell, William Cole; Jo, Jeanyoung et al. (2018) The Pseudomonas aeruginosa Complement of Lactate Dehydrogenases Enables Use of d- and l-Lactate and Metabolic Cross-Feeding. MBio 9:
Yurko, Nathan M; Manley, James L (2018) The RNA polymerase II CTD ""orphan"" residues: Emerging insights into the functions of Tyr-1, Thr-4, and Ser-7. Transcription 9:30-40
Tomljanovic, Zeljko; Patel, Mitesh; Shin, William et al. (2018) ZCCHC17 is a master regulator of synaptic gene expression in Alzheimer's disease. Bioinformatics 34:367-371
Rajbhandari, Presha; Lopez, Gonzalo; Capdevila, Claudia et al. (2018) Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma. Cancer Discov 8:582-599
Burn, Sally F; Washkowitz, Andrew J; Gavrilov, Svetlana et al. (2018) Postimplantation Mga expression and embryonic lethality of two gene-trap alleles. Gene Expr Patterns 27:31-35
Wei, Spencer C; Levine, Jacob H; Cogdill, Alexandria P et al. (2017) Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade. Cell 170:1120-1133.e17
Lavin, Yonit; Kobayashi, Soma; Leader, Andrew et al. (2017) Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses. Cell 169:750-765.e17
Chevrier, St├ęphane; Levine, Jacob Harrison; Zanotelli, Vito Riccardo Tomaso et al. (2017) An Immune Atlas of Clear Cell Renal Cell Carcinoma. Cell 169:736-749.e18

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