Training Program in Marine Biotechnology This renewal application for a Training Program (TP) in Marine Biotechnology at UC San Diego represents the third cycle of requested support for this unique program. As a discipline, marine biotechnology has seen considerable advancement in recent years with an increasing number of valuable products being derived from or inspired by marine life forms. Hence, this TP has the goal of training a diverse workforce with the appropriate multidisciplinary education to work at the confluence of marine science, organic chemistry, biochemistry, pharmacology, genomics, cell biology, and computational science. In this immediately past cycle of 4 years, we demonstrated that the program could operate as envisioned by both the TP leadership and the NIH with a superb group of highly talented and enthusiastic trainees, one---third of whom are members of underrepresented minority groups. These trainees are participating in a robust curriculum in Marine Biotechnology, involved in a student---run invited seminar speaker program and year---end research retreat, have completed their Responsible Conduct in Research training on time, and have engaged in the unique Industrial Internship feature of the program during their period of NIH trainee support. In this renewal application, four senior faculty no longer involved in graduate student training have retired from the TP, and five new and diverse faculty in sciences related to marine biotechnology have been added. This Training Program has developed considerable campus recognition, and is highly appreciated and supported by campus administration, including generous matching funds as detailed in this proposal and support letters. The proposed path forward for this TP in the next cycle involves additional solidification of the policies and procedures of this training program, further enhancement of our underrepresented minority and people with disabilities recruitment, and refinement of the running of the program with greater use of our External Advisory Committee and other participant feedback.

Public Health Relevance

Training Program in Marine Biotechnology This Training Program seeks to meet an unfilled need to train an expert and diverse workforce in the field of marine biotechnology. This involves a rigorous didactic coursework program, enriching seminar and symposium features, and a broadening industrial internship.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM067550-13
Application #
9518945
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Brown, Patrick
Project Start
2004-07-01
Project End
2020-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
13
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of California, San Diego
Department
Zoology
Type
Earth Sciences/Resources
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Skiba, Meredith A; Sikkema, Andrew P; Moss, Nathan A et al. (2018) Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module. ACS Chem Biol 13:1640-1650
Gallagher, Kelley A; Wanger, Greg; Henderson, Jane et al. (2017) Ecological implications of hypoxia-triggered shifts in secondary metabolism. Environ Microbiol 19:2182-2191
Skiba, Meredith A; Sikkema, Andrew P; Moss, Nathan A et al. (2017) A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit. ACS Chem Biol 12:3039-3048
Kinnel, Robin B; Esquenazi, Eduardo; Leao, Tiago et al. (2017) A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens. J Nat Prod 80:1514-1521
Naman, C Benjamin; Rattan, Ramandeep; Nikoulina, Svetlana E et al. (2017) Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium. J Nat Prod 80:625-633
León-Zayas, Rosa; Peoples, Logan; Biddle, Jennifer F et al. (2017) The metabolic potential of the single cell genomes obtained from the Challenger Deep, Mariana Trench within the candidate superphylum Parcubacteria (OD1). Environ Microbiol 19:2769-2784
Wilson, Christopher M; Roa, Jinae N; Cox, Georgina K et al. (2016) Introducing a novel mechanism to control heart rate in the ancestral Pacific hagfish. J Exp Biol 219:3227-3236
El Gamal, Abrahim; Agarwal, Vinayak; Rahman, Imran et al. (2016) Enzymatic Reductive Dehalogenation Controls the Biosynthesis of Marine Bacterial Pyrroles. J Am Chem Soc 138:13167-13170
Petras, Daniel; Nothias, Louis-Félix; Quinn, Robert A et al. (2016) Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats. Anal Chem 88:10775-10784
Bertin, Matthew J; Demirkiran, Ozlem; Navarro, Gabriel et al. (2016) Kalkipyrone B, a marine cyanobacterial ?-pyrone possessing cytotoxic and anti-fungal activities. Phytochemistry 122:113-118

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