The practice of Anesthesia is rapidly expanding beyond the boundaries of the operating room. Increasingly, anesthesiologists are taking a roles is critical care, the management of pain, rapid response to inpatient emergencies, in addition to clinical and basic science research. Rapidly changing healthcare environments require that the next generation of leaders in anesthesia be broadly trained, both clinically and in basic and translational science. The goals of this post-doctoral training program are to provide young scientists with outstanding experiences in basic and translational research arenas. The primary focus of the program will be to train the next generation of physician scholars (those having MD or MD/PhD degrees). This program will fund 2 fellows per year for 2 years, meaning 4 funded slots per year. We envision four tracks for research training, each of which will draw on outstanding expertise at Yale, both within the Department of Anesthesia, and in other programs in the Medical Center and the University. The Vascular Biology track will leverage trainers within Anesthesia, in conjunction with the well-established and interdisciplinary Vascular Biology and Therapeutics (VBT) program at Yale. The Biology of Inflammation/Immunity track will involve trainers from the Department of Immunobiology and from the Human Translational Immunology, both of which include world-class investigators. The Bioengineering track will include investigators from Anesthesia, as well as the Bioengineering Department and outstanding groups in Diagnostic Imaging. The fourth track, Clinical Research, will also leverage training resources within the Department, as well as the recently-awarded CTSA program at Yale. To further advance the training of physician scientists, and independent of this T32 application, we have recently established a Resident Scholars Program (RSP). The RSP is funded entirely by the Anesthesia department, and provides intensive mentoring in research during the 3 years of anesthesia residency. We anticipate that many of these highly select residents in the RSP will be excellent candidates for enrollment in this T32 post-doctoral training program upon completion of their residency.

Public Health Relevance

This grant will fund advanced research training for clinical anesthesiologists, in both basic science and in clinically oriented research. By providing outstanding training to practicing physicians, we are improving the delivery and advancement of healthcare nationwide, because these trained physicians will drive the development of new therapies and improved ways of caring for patients.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Cole, Alison E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
Schools of Medicine
New Haven
United States
Zip Code
Gruenbaum, Shaun E; Dhaher, Roni; Rapuano, Amedeo et al. (2018) Effects of Branched-Chain Amino Acid Supplementation on Spontaneous Seizures and Neuronal Viability in a Model of Mesial Temporal Lobe Epilepsy. J Neurosurg Anesthesiol :
Yang, Yang; Adi, Talia; Effraim, Philip R et al. (2018) Reverse pharmacogenomics: carbamazepine normalizes activation and attenuates thermal hyperexcitability of sensory neurons due to Nav 1.7 mutation I234T. Br J Pharmacol 175:2261-2271
Engler, Alexander J; Le, Andrew V; Baevova, Pavlina et al. (2018) Controlled gas exchange in whole lung bioreactors. J Tissue Eng Regen Med 12:e119-e129
Ghaedi, Mahboobe; Le, Andrew V; Hatachi, Go et al. (2018) Bioengineered lungs generated from human iPSCs-derived epithelial cells on native extracellular matrix. J Tissue Eng Regen Med 12:e1623-e1635
Brotfain, Evgeni; Kutz, Ruslan; Grinshpun, Julia et al. (2018) Blood Glutamate Reducing Effect of Hemofiltration in Critically Ill Patients. Neurotox Res 33:300-308
Schonberger, Robert B; Nwozuzu, Adambeke; Zafar, Jill et al. (2018) Elevated preoperative blood pressures in adult surgical patients are highly predictive of elevated home blood pressures. J Am Soc Hypertens 12:303-310
Tham, See Wan; Li, Li; Effraim, Philip et al. (2017) Between fire and ice: refractory hypothermia and warmth-induced pain in inherited erythromelalgia. BMJ Case Rep 2017:
Tietjen, Gregory T; Hosgood, Sarah A; DiRito, Jenna et al. (2017) Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys. Sci Transl Med 9:
Nwozuzu, Adambeke; Fontes, Manuel L; Schonberger, Robert B (2016) Mobile Extracorporeal Membrane Oxygenation Teams: The North American Versus the European Experience. J Cardiothorac Vasc Anesth 30:1441-1448
Tsuchiya, Tomoshi; Mendez, Julio; Calle, Elizabeth A et al. (2016) Ventilation-Based Decellularization System of the Lung. Biores Open Access 5:118-26

Showing the most recent 10 out of 61 publications