Anesthesiology research has grown well beyond a search for drug mechanisms of action. The expertise of anesthesiologists now extends to all aspects of preoperative care. This competing renewal has been written with that in mind. It is our intention to provide talented and dedicated individuals with adequate time to delve into cutting edge research under the guidance of highly successful mentors. It is a goal of this department to contribute outstanding clinician-scientists to the leadership pool for the next generation of anesthesiologists and funds requested in this proposal will be an important tool in that process. The post-doctoral training program will employ five tracks. All trainees will be involved full-time, 40 hours per week, in research training, whether it be laboratory research, didactic training, preparing manuscripts and grants, or attending meetings and conferences. The five training tracks are designed to provide trainees with a breadth of basic science and clinical research opportunities, in areas that are directly relevant to anesthetic practice: Neurobiology, Vascular Biology, Inflammation/Immunity, Bioengineering, and Clinical Research. The five tracks also draw upon particular strengths at Yale, encompassing faculty from within the Medical School, and also from the University campus. Mentors have been strategically selected, and have the following qualities: i) history of outstanding training and mentorship - for younger mentors, a history of excellent interactions with junior house staff and an exciting and clinically relevant research program are deemed sufficient for inclusion;ii) research focus in one or more of the five selected training tracks;iii) clear desire to train productive clinician scientists in Anesthesia. While some mentors'interests fall clearly into one of the five tracks, many mentors have research foci that fall into more than one track. In addition, mentors having expertise across multiple scientific areas can provide a richer and more interdisciplinary training experience, which will be profoundly beneficial to trainees after they emerge from the T32 program to begin independent careers.
This post-doctoral Training Grant in Anesthesia research will prepare young physician scientists to become independent researchers in areas of medical science that are pertinent to the practice of anesthesiology. Areas of scientific focus include Neurobiology, Vascular Biology, Immunology, Bioengineering, and Clinical Research.
|Gruenbaum, Shaun E; Dhaher, Roni; Rapuano, Amedeo et al. (2018) Effects of Branched-Chain Amino Acid Supplementation on Spontaneous Seizures and Neuronal Viability in a Model of Mesial Temporal Lobe Epilepsy. J Neurosurg Anesthesiol :|
|Yang, Yang; Adi, Talia; Effraim, Philip R et al. (2018) Reverse pharmacogenomics: carbamazepine normalizes activation and attenuates thermal hyperexcitability of sensory neurons due to Nav 1.7 mutation I234T. Br J Pharmacol 175:2261-2271|
|Engler, Alexander J; Le, Andrew V; Baevova, Pavlina et al. (2018) Controlled gas exchange in whole lung bioreactors. J Tissue Eng Regen Med 12:e119-e129|
|Ghaedi, Mahboobe; Le, Andrew V; Hatachi, Go et al. (2018) Bioengineered lungs generated from human iPSCs-derived epithelial cells on native extracellular matrix. J Tissue Eng Regen Med 12:e1623-e1635|
|Brotfain, Evgeni; Kutz, Ruslan; Grinshpun, Julia et al. (2018) Blood Glutamate Reducing Effect of Hemofiltration in Critically Ill Patients. Neurotox Res 33:300-308|
|Schonberger, Robert B; Nwozuzu, Adambeke; Zafar, Jill et al. (2018) Elevated preoperative blood pressures in adult surgical patients are highly predictive of elevated home blood pressures. J Am Soc Hypertens 12:303-310|
|Tietjen, Gregory T; Hosgood, Sarah A; DiRito, Jenna et al. (2017) Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys. Sci Transl Med 9:|
|Tham, See Wan; Li, Li; Effraim, Philip et al. (2017) Between fire and ice: refractory hypothermia and warmth-induced pain in inherited erythromelalgia. BMJ Case Rep 2017:|
|Nwozuzu, Adambeke; Fontes, Manuel L; Schonberger, Robert B (2016) Mobile Extracorporeal Membrane Oxygenation Teams: The North American Versus the European Experience. J Cardiothorac Vasc Anesth 30:1441-1448|
|Tsuchiya, Tomoshi; Mendez, Julio; Calle, Elizabeth A et al. (2016) Ventilation-Based Decellularization System of the Lung. Biores Open Access 5:118-26|
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