The T32 Program in Genetics and Genomics at Harvard Medical School trains 6 student per year to prepare them for careers advancing our understanding of the fundamental mechanisms of hereditary disease, and genomic methodologies. This is a proposal for a supplement that will allow us to develop new programming that advances diversity of our students, and promotes a sense of inclusion across the program. The proposal is designed to develop and test programs that can, if successful, become part of the orientation activities and coursework for all of the PhD students in life sciences at Harvard Medical School. To do so we will 1) develop novel orientation events that will establish an inclusive culture and community, and will involve both incoming students and more senior members of the community 2) work with Diversity Fellows from the School of Education to initiate new programming focused on sustaining inclusive learning environments in the lab, activities that can be incorporated into the ongoing Conduct of Science course, and 3) host a Symposium on Bias in Genetics and Genomics Research, to demonstrate the importance of diversity and inclusion in our science, as well as in our new scientists. These activities are designed to enhance the training program in genetics and genomics and extend the impact of these efforts to the broader HMS community and scientific community.
Many human diseases, including diabetes, cancer, and heart disease are caused by genetic factors that are inherited from one generation to the next. However, our understanding of how genetics contributes to most diseases is poor and requires further research. Our research training program will teach Ph.D. students in the most modern areas of genetics so that they can apply their knowledge to advance our understanding in the areas of human biology and disease.
| Thompson, David B; Aboulhouda, Soufiane; Hysolli, Eriona et al. (2018) The Future of Multiplexed Eukaryotic Genome Engineering. ACS Chem Biol 13:313-325 |
| Pan, Joshua; Meyers, Robin M; Michel, Brittany C et al. (2018) Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens. Cell Syst 6:555-568.e7 |
| Yu, Ruby; Wang, Xiaoyi; Moazed, Danesh (2018) Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation. Nature 558:615-619 |
| Turcot, Valérie (see original citation for additional authors) (2018) Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet 50:26-41 |
| Marouli, Eirini (see original citation for additional authors) (2017) Rare and low-frequency coding variants alter human adult height. Nature 542:186-190 |
| Cummings, Beryl B; Marshall, Jamie L; Tukiainen, Taru et al. (2017) Improving genetic diagnosis in Mendelian disease with transcriptome sequencing. Sci Transl Med 9: |
| Senaratne, T Niroshini; Joyce, Eric F; Nguyen, Son C et al. (2016) Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei. PLoS Genet 12:e1006169 |
| Quintos, Jose Bernardo; Guo, Michael H; Dauber, Andrew (2015) Idiopathic short stature due to novel heterozygous mutation of the aggrecan gene. J Pediatr Endocrinol Metab 28:927-32 |
| Kerns, Sarah L; Guevara-Aguirre, Jaime; Andrew, Shayne et al. (2014) A novel variant in CDKN1C is associated with intrauterine growth restriction, short stature, and early-adulthood-onset diabetes. J Clin Endocrinol Metab 99:E2117-22 |
| Guo, Michael H; Shen, Yiping; Walvoord, Emily C et al. (2014) Whole exome sequencing to identify genetic causes of short stature. Horm Res Paediatr 82:44-52 |
