The primary objective of the proposed training program in reproductive biology (RBTP) is to continue offering predoctoral and postdoctoral training to individuals who demonstrate potential for developing into independent investigators in the field of reproductive biology. The renewal application by including multidisciplinary interests expands the horizon of training for students. This will better prepare their career paths in the 21st century and present them with opportunities to make significant scientific contribution to reproductive biology. This renewal application focuses on the current excitement in scientific innovations, opportunities and advances in biomedical sciences with evolving technologies. The proposed RBTP has been developed within the current mission of the NIH roadmap to multidisciplinary approaches to research endeavors. This mission can best be accomplished if students are trained in an environment where specific biological problems are addressed using contemporary knowledge in developmental biology, physiological genomics, proteomics, signal transduction, and molecular and cellular biology. The present environment at Vanderbilt is highly conducive to such training due to a broad based interactive group of 13 investigators spanning several departments and thematic areas, and the recent establishment of genomics, proteomics, lipidomics and imaging centers on the campus with state-of-the-art facilities. Training will occur with major emphasis in: 1) gametogenesis, sperm functions and fertilization, (Greenstein, Olson, Drummond-Barbosa and Waterman);2) uterine biology (Das, Dey, Ong and Paria);3) embryogenesis, development and implantation (Das, Dey, Chiang, Lee and Paria);and 4) genetic regulation of gonadotropin secretion (Phillips). These areas of research training require the infusion and active participation of preceptors who are experts in developmental biology, signal transductions, genomics and proteomics (Lee, Caprioli, and Sealy).

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Taymans, Susan
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
Obstetrics & Gynecology
Schools of Medicine
United States
Zip Code
Plank, Jennifer L; Suflita, Michael T; Galindo, Cristi L et al. (2014) Transcriptional targets of Foxd3 in murine ES cells. Stem Cell Res 12:233-40
Bruner-Tran, K L; Herington, J L; Duleba, A J et al. (2013) Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology. Minerva Ginecol 65:199-213
Jodoin, Jeanne N; Sitaram, Poojitha; Albrecht, Todd R et al. (2013) Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Mol Biol Cell 24:2954-65
Suflita, Michael T; Pfaltzgraff, Elise R; Mundell, Nathan A et al. (2013) Ground-state transcriptional requirements for skin-derived precursors. Stem Cells Dev 22:1779-88
Sitaram, Poojitha; Anderson, Michael A; Jodoin, Jeanne N et al. (2012) Regulation of dynein localization and centrosome positioning by Lis-1 and asunder during Drosophila spermatogenesis. Development 139:2945-54
Jodoin, Jeanne N; Shboul, Mohammad; Sitaram, Poojitha et al. (2012) Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. Mol Biol Cell 23:4713-24
Nelms, Brian L; Labosky, Patricia A (2011) A predicted hairpin cluster correlates with barriers to PCR, sequencing and possibly BAC recombineering. Sci Rep 1:106
Nelms, Brian L; Pfaltzgraff, Elise R; Labosky, Patricia A (2011) Functional interaction between Foxd3 and Pax3 in cardiac neural crest development. Genesis 49:10-23
Herington, Jennifer L; Bruner-Tran, Kaylon L; Lucas, John A et al. (2011) Immune interactions in endometriosis. Expert Rev Clin Immunol 7:611-26
LaFever, Leesa; Feoktistov, Alexander; Hsu, Hwei-Jan et al. (2010) Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary. Development 137:2117-26

Showing the most recent 10 out of 31 publications