This application seeks to continue the tradition of University-wide training in reproductive biology at Johns Hopkins University by renewing a training program in the reproductive sciences that was first funded in 1984.The goals of this Program continue to be to produce predoctoral trainees with rigorous education in the disciplines that constitute the foundation of reproductive biology, including physiology, biochemistry, molecular biology, cell biology, genetics, developmental biology and endocrinology;and to produce trainees who are thoroughly grounded in the conceptualization, design and interpretation of hypothesis-driven experimental studies. Additionally, the trainees are expected to emerge from their training experience with an appreciation of clinical and public health issues related to the reproductive sciences. Prospective trainees will have been admitted to a participating department or program. After a year, those who have demonstrated a strong academic record, selected a preceptor of the Training Program in whose laboratory to conduct research, and chosen to conduct research in an area with clear relevance to the reproductive sciences will be eligible for the Training Program. The nine proposed preceptors are from the Johns Hopkins University School of Public Health (T. Brown, J. Evans, W. Wright, B. Zirkin), School of Medicine (J. Jarow, E. Matunis, G. Seydoux), and School of Arts and Sciences (R. Cone, G. Ball). Drs. Ball, Matunis and Seydoux are new to this Training Program. Their addition will augment research opportunities for trainees, and will greatly increase the pool of students from which we will choose well-qualified trainees. All trainees will be required to attend and participate in a monthly University-wide reproductive biology seminar series, a weekly journal club and an Annual Research Retreat. All of the training faculty members have external funding necessary to support the investigations of the trainees, and they have strong training records. In past years, this Program has produced exceptionally productive scientists, most of who continue to conduct research and/or to teach in the area of reproductive biology. We expect the expanded prospective trainee pool, expanded faculty and richer environment of the Training Program to improve an already strong Program.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007276-25
Application #
8072022
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Taymans, Susan
Project Start
1984-07-01
Project End
2013-04-30
Budget Start
2011-05-01
Budget End
2013-04-30
Support Year
25
Fiscal Year
2011
Total Cost
$177,616
Indirect Cost
Name
Johns Hopkins University
Department
Biochemistry
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Matthews, Lauren M; Evans, Janice P (2014) ?-endosulfine (ENSA) regulates exit from prophase I arrest in mouse oocytes. Cell Cycle 13:1639-49
Beattie, Matthew C; Chen, Haolin; Fan, Jinjiang et al. (2013) Aging and luteinizing hormone effects on reactive oxygen species production and DNA damage in rat Leydig cells. Biol Reprod 88:100
Wang, Jennifer T; Seydoux, Geraldine (2013) Germ cell specification. Adv Exp Med Biol 757:17-39
Marcello, Matthew R; Jia, Weitao; Leary, Julie A et al. (2011) Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm. J Biol Chem 286:13060-70
Marcello, Matthew R; Evans, Janice P (2010) Multivariate analysis of male reproductive function in Inpp5b-/- mice reveals heterogeneity in defects in fertility, sperm-egg membrane interaction and proteolytic cleavage of sperm ADAMs. Mol Hum Reprod 16:492-505
Kleitz-Nelson, H K; Cornil, C A; Balthazart, J et al. (2010) Differential effects of central injections of D1 and D2 receptor agonists and antagonists on male sexual behavior in Japanese quail. Eur J Neurosci 32:118-29
Merritt, Christopher; Seydoux, Geraldine (2010) The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the expression of synaptonemal complex proteins in germline stem cells. Development 137:1787-98
Kleitz-Nelson, H K; Dominguez, J M; Cornil, C A et al. (2010) Is sexual motivational state linked to dopamine release in the medial preoptic area? Behav Neurosci 124:300-4
Kleitz, Hayley K; Cornil, Charlotte A; Balthazart, Jacques et al. (2009) Species differences in the relative densities of D1- and D2-like dopamine receptor subtypes in the Japanese quail and rats: an in vitro quantitative receptor autoradiography study. Brain Behav Evol 73:81-90
Merritt, Christopher; Rasoloson, Dominique; Ko, Darae et al. (2008) 3'UTRs are the primary regulators of gene expression in the C. elegans germline. Curr Biol 18:1476-82

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