This Competing Continuation Application for a Ruth L. Kirschstein Institutional National Research Service Award (T32) is focused on the postdoctoral training of M.D., M.D.-Ph.D., and Ph.D. candidates to prepare them to pursue independent careers as successful Clinician-Scientists and/or Biomedical Research Scientists, whose primary interest is the cellular and molecular mechanisms of human disease. Its primary training goal is the development of core research competencies through both informal and structured didactic exercises, coupled with an indepth mentored research experience, in a nurturing and supportive academic medical center environment. The programmatic emphasis is on understanding the basic pathogenetic mechanisms underlying major disease processes that affect the cardiovascular, pulmonary, hematopoietic and immune systems, through the application of the multidisciplinary research tools and strategies of modern cellular and molecular biology, immunology, genetics and genomics, integrative physiology and bioinformatics. The current Training Program, sponsored by the National Heart, Lung and Blood Institute, has been in continuous existence since 1958, and is based in the Department of Pathology at the Brigham and Women's Hospital, a primary teaching affiliate of Harvard Medical School (HMS). While the Training Program's Core Faculty is comprised primarily of clinician-scientists and basic biomedical researchers in the Department of Pathology, trainees also, are encouraged to avail themselves of a wide spectrum of opportunities afforded by research mentors/laboratories in the Longwood Medical Area, including HMS basic science departments (e.g., Pathology, Cell Biology, Systems Biology), the Dana-Farber Cancer Center, the Beth Israel-Deaconess Medical Center, the Harvard-Partners Center for Human Genetics and Genomics, and the Harvard-MIT Health Sciences and Technology Program. Trainees are selected from a national pool of applicants, and the Program's emphasis is on a research training experience tailored to a given candidate's background, scientific interests and career goals.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007627-25
Application #
7629059
Study Section
Special Emphasis Panel (ZHL1-CSR-G (F1))
Program Officer
Commarato, Michael
Project Start
1985-07-01
Project End
2010-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
25
Fiscal Year
2009
Total Cost
$420,133
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Basu, Sankha S; Randall, Elizabeth C; Regan, Michael S et al. (2018) In Vitro Liquid Extraction Surface Analysis Mass Spectrometry (ivLESA-MS) for Direct Metabolic Analysis of Adherent Cells in Culture. Anal Chem 90:4987-4991
McConnell, Alicia M; Mito, Jeffrey K; Ablain, Julien et al. (2018) Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion. Dev Biol :
Palte, Michael J; Basu, Sankha S; Dahlin, Jameson L et al. (2018) Development and Validation of an Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for the Concurrent Measurement of Gabapentin, Lamotrigine, Levetiracetam, Monohydroxy Derivative of Oxcarbazepine, and Zonisamide Concentrations in Se Ther Drug Monit 40:469-476
Al Hmada, Youssef; Schaefer, Inga-Marie; Fletcher, Christopher D M (2018) Hibernoma Mimicking Atypical Lipomatous Tumor: 64 Cases of a Morphologically Distinct Subset. Am J Surg Pathol 42:951-957
Dobry, Allison S; Zogg, Cheryl K; Hodi, F Stephen et al. (2018) Management of metastatic melanoma: improved survival in a national cohort following the approvals of checkpoint blockade immunotherapies and targeted therapies. Cancer Immunol Immunother 67:1833-1844
Schaefer, Inga-Marie; Hornick, Jason L (2018) Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update. Adv Anat Pathol 25:400-412
Ablain, Julien; Xu, Mengshu; Rothschild, Harriet et al. (2018) Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma. Science 362:1055-1060
Schaefer, Inga-Marie; Fletcher, Jonathan A; Nielsen, G Petur et al. (2018) Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy. Cancer Cytopathol 126:552-566
Sage, Peter T; Schildberg, Frank A; Sobel, Raymond A et al. (2018) Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function. J Immunol 200:2592-2602
Nudel, K; Zhao, X; Basu, S et al. (2018) Genomics of Corynebacterium striatum, an emerging multidrug-resistant pathogen of immunocompromised patients. Clin Microbiol Infect 24:1016.e7-1016.e13

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