Our training program in pulmonary disease provides comprehensive research training for individuals with a serious commitment to a career in lung biology and biomedical research, particularly as it interfaces with clinical pulmonary medicine. Our primary premise has long been that lung disease represents major health problems in the U.S. and that progress toward improved understanding of the pathobiology of these diseases are required to make progress toward treatment and prevention. The program has a long history (30m years), training numerous physicians and scientists who have subscribed to this mission, and have become leaders in academic pulmonary medicine. The program is under new leadership and strives to maintain the previous scientific and training success, while adapting the next generation of researchers to new basic and translational science and technology. Recent changes have included expanded resources (recruitment of 24 new faculty members, and doubling the laboratory space). This has allowed us to broaden the scope of research questions related to lung biology, and attack the problems at the most basic and translational levels incorporating new cores in the Lung Biology ad Clinical Center Center and Harvard Medical Center. We have also enhanced our didactic program and further solidified program organization for oversight and mentoring of trainees. We identify trainees with a demonstrated interest in a research career. We also identify an environment where these individuals can pursue a problem of interest and in which creative and solid thinking combined with state-of-the-art technology is being used to pursue the problem, and provide them with the tools and mind-set to attack other problems in the future. Finally, we provide a prolonged period of support so that trainees are prepared to ultimately become a productive independent investigator, and the next leaders in pulmonary academics. Of the 38 trainees who have completed the program, 35 trainees in the last 10 years (92%) remain in academic medicine and research, 2 trainees are performing clinical research in industry, and only one trainee in the past decade is now in private practice. These trainees obtained 36 grant awards consisting of 20 NIH mentorship awards (K-and F Awards), 5 independent R-awards, 1 Project Leader on PPG, 2 Clinical Research Network grants, 3 Parker B. Francis awards, and 6 foundation awards (ATS/ALA, CF foundation), and have published 191 papers with their training grant mentors. As the Program Director of this training program, he will continue to work with the utmost enthusiasm and energy to ensure that the trainees of our training program will continue to excel and contribute significantly to the academic pulmonary community.

Public Health Relevance

Training program in pulmonary disease provides comprehensive research training for individuals with a serious commitment to a career in biomedical research focused on lung disease. Our primary goal is to train the next generation of physician scientist and scientist to become independent researchers in academic medicine to better understand the pathogenesis of lung disease and identify new therapeutic modalities in lung disease.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZHL1)
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Tigno, Xenia
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Brigham and Women's Hospital
United States
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González, Germán; Ash, Samuel Y; San José Estépar, Raúl et al. (2018) Reply to Mummadi et al.: Overfitting and Use of Mismatched Cohorts in Deep Learning Models: Preventable Design Limitations. Am J Respir Crit Care Med 198:545
Ash, Samuel Y; Harmouche, Rola; Ross, James C et al. (2018) Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in the COPDGene Cohort. Radiology 288:600-609
Courtwright, Andrew M; Zaleski, Derek; Gardo, Lisa et al. (2018) Causes, Preventability, and Cost of Unplanned Rehospitalizations Within 30 Days of Discharge After Lung Transplantation. Transplantation 102:838-844
Taglauer, Elizabeth; Abman, Steven H; Keller, Roberta L (2018) Recent advances in antenatal factors predisposing to bronchopulmonary dysplasia. Semin Perinatol 42:413-424
Cao, Severine; Courtwright, Andrew M; Lamattina, Anthony M et al. (2018) The impact of screening method on HLA antibody detection before and after lung transplantation: A prospective pilot study. J Heart Lung Transplant 37:531-533
Ash, Samuel Y; Rahaghi, Farbod N; Come, Carolyn E et al. (2018) Pruning of the Pulmonary Vasculature in Asthma. The Severe Asthma Research Program (SARP) Cohort. Am J Respir Crit Care Med 198:39-50
Kalhan, Ravi; Dransfield, Mark T; Colangelo, Laura A et al. (2018) Respiratory Symptoms in Young Adults and Future Lung Disease. The CARDIA Lung Study. Am J Respir Crit Care Med 197:1616-1624
González, Germán; Ash, Samuel Y; Vegas-Sánchez-Ferrero, Gonzalo et al. (2018) Disease Staging and Prognosis in Smokers Using Deep Learning in Chest Computed Tomography. Am J Respir Crit Care Med 197:193-203
Miller, Ezra R; Putman, Rachel K; Vivero, Marina et al. (2018) Histopathology of Interstitial Lung Abnormalities in the Context of Lung Nodule Resections. Am J Respir Crit Care Med 197:955-958
Baron, Rebecca M; Kwon, Min-Young; Castano, Ana P et al. (2018) Frontline Science: Targeted expression of a dominant-negative high mobility group A1 transgene improves outcome in sepsis. J Leukoc Biol 104:677-689

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